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Titolo:
Activation of the ventrolateral periaqueductal gray reduces locomotion butnot mean arterial pressure in awake, freely moving rats
Autore:
Morgan, MM; Carrive, P;
Indirizzi:
Washington State Univ, Dept Psychol, Vancouver, WA 98686 USA Washington State Univ Vancouver WA USA 98686 hol, Vancouver, WA 98686 USA Univ New S Wales, Sch Anat, Sydney, NSW, Australia Univ New S Wales Sydney NSW Australia , Sch Anat, Sydney, NSW, Australia
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 102, anno: 2001,
pagine: 905 - 910
SICI:
0306-4522(2001)102:4<905:AOTVPG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATION-PRODUCED ANALGESIA; CONDITIONED FEAR; FOS EXPRESSION; MIDBRAIN; ORGANIZATION; PROJECTIONS; LESIONS; MEDULLA; REGION; MICROINJECTIONS;
Keywords:
defensive freezing; quiescence; immobility; cardiovascular regulation; pain modulation; excitatory amino acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Morgan, MM Washington State Univ, Dept Psychol, Vancouver, WA 98686 USA Washington State Univ Vancouver WA USA 98686 ver, WA 98686 USA
Citazione:
M.M. Morgan e P. Carrive, "Activation of the ventrolateral periaqueductal gray reduces locomotion butnot mean arterial pressure in awake, freely moving rats", NEUROSCIENC, 102(4), 2001, pp. 905-910

Abstract

Activation of the ventrolateral periaqueductal gray produces immobility and antinociception. It has been argued that these behaviors are part of either a defensive fear response to threat or a recuperative quiescence response to deep tissue injury. Data collected in anesthetized animals showing that activation of the ventrolateral peraqueductal gray has a hypotensive effect supports the quiescence hypothesis. Our objective was to determine whether activation of the ventrolateral periaqueductal gray in awake, freely moving rats results in a decrease in blood pressure as it does in anesthetizedanimals. Changes in blood pressure produced by microinjection of the neuroexcitant D,L-homocysteic acid were measured using radio telemetry while rats were awake and while anesthetized with pentobarbital. Consistent with earlier reports. microinjection of D,L-homocysteic acid into the ventrolateralperiaqueductal gray caused a decrease in blood pressure in anesthetized rats. In contrast, microinjection at the same ventrolateral periaqueductal gray sites while rats were awake had no effect on blood pressure. even thoughthe animals became immobile and hear? rare decreased. Thus, the immobilityevoked from ventrolateral periaqueductal gray is not associated with a fall in mean arterial pressure. Two conclusions can be drawn from these data. (1) Caution must be used in generalizing from data collected in anesthetized animals. (2) The ventrolateral periaqueductal gray is as likely to contribute to defensive fear as torecuperative quiescence. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 09/04/20 alle ore 13:20:47