Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A decrease in size and number of basal forebrain cholinergic neurons is paralleled by diminished hippocampal cholinergic innervation in mice lacking leukocyte common antigen related protein tyrosine phosphatase activity
Autore:
Van Lieshout, EMM; Van der Heijden, I; Hendriks, WJAJ; Van der Zee, CEEM;
Indirizzi:
Univ Nijmegen, Med Ctr St Radboud, Inst Cellular Signalling, Dept Cell Biol, NL-6525 EK Nijmegen, Netherlands Univ Nijmegen Nijmegen Netherlands NL-6525 EK 5 EK Nijmegen, Netherlands
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 102, anno: 2001,
pagine: 833 - 841
SICI:
0306-4522(2001)102:4<833:ADISAN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; SPATIAL MEMORY IMPAIRMENTS; AGED RATS; PROJECTION PATTERNS; ALZHEIMERS-DISEASE; FACTOR RECEPTOR; NGF RECEPTOR; CRYP-ALPHA; PTP-SIGMA; LAR;
Keywords:
cell-matrix interaction; cholinergic fibre; cholinergic neuron; dentate gyrus; mutant mouse; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Van der Zee, CEEM Univ Nijmegen, Med Ctr St Radboud, Inst Cellular Signalling, Dept Cell Biol, Adelbertusplein 1, NL-6525 EK Nijmegen, Netherlands Univ Nijmegen Adelbertusplein 1 Nijmegen Netherlands NL-6525 EK
Citazione:
E.M.M. Van Lieshout et al., "A decrease in size and number of basal forebrain cholinergic neurons is paralleled by diminished hippocampal cholinergic innervation in mice lacking leukocyte common antigen related protein tyrosine phosphatase activity", NEUROSCIENC, 102(4), 2001, pp. 833-841

Abstract

The leukocyte common antigen-related (LAR) receptor, composed of an extracellular region with three immunoglobulin-like and eight fibronectin type III-like domains, and a cytoplasmic region containing two protein tyrosine phosphatase domains, is thought to play a role in axonal outgrowth and guidance during neural development. LAR mutant mice were generated completely tacking the two cytoplasmic protein tyrosine phosphatase domains, resulting inthe loss of ability to bind intracellular associating proteins, but (may be) still containing the ability to perform extracellular functions. A reduction in size of basal forebrain cholinergic neurons and diminished hippocampal innervation reponed for knockout mice that contain a leaky gene trap inserted into the 5' part of the LAR gene [Yeo T. T. et al. (1997) J. Neurusci. Res. 47, 348-360] warranted a computer-assisted quantitative image analysis throughout the basal forebrain and hippocampus of our LAR mutant mice. The total number, longest diameter and cell body area were calculated for the choline acetyltransferase-positive neurons in the medial septum and vertical diagonal band, and optical density measurements were performed to determine the extent of acetyl cholinesterase-positive fibre innervation of thedifferent layers in the dentate gyrus. In LAR mutant mice, the number of cholinergic cells was significantly reduced (similar to 25%) in the verticaldiagonal band. Also. the cross-sectional area of the cholinergic neurons in the medial septum and vertical diagonal band was reduced (5%). These findings were paralleled by a diminished cholinergic innervation of the supragranular (18%) and molecular (4%) layers of the dentate gyrus. Thus, LAR protein tyrosine phosphatase activity appears crucial for size, number and target projection of basal forebrain cholinergic neurons, further strengthening a role for LAR in CNS development. (C) 2001 IBRO. Publishedby Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 23:17:49