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Titolo:
Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: Comparison with noradrenergic neurons
Autore:
Ferencz, I; Leanza, G; Nanobashvili, A; Kokaia, Z; Kokaia, M; Lindvall, O;
Indirizzi:
Univ Lund Hosp, Sect Restorat Neurol, Wallenberg Neurosci Ctr, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 rg Neurosci Ctr, S-22185 Lund, Sweden Univ Catania, Dept Physiol Sci, Catania, Italy Univ Catania Catania Italy iv Catania, Dept Physiol Sci, Catania, Italy Univ Trieste, Dept Physiol & Pathol, I-34127 Trieste, Italy Univ Trieste Trieste Italy I-34127 siol & Pathol, I-34127 Trieste, Italy
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 102, anno: 2001,
pagine: 819 - 832
SICI:
0306-4522(2001)102:4<819:SCNSSD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS CERULEUS STIMULATION; MESSENGER-RNA REGULATION; EPILEPSY-PRONE RATS; NEUROPEPTIDE-Y; EPILEPTIFORM ACTIVITY; NORADRENALINE RELEASE; PYRAMIDAL CELLS; NOREPINEPHRINE DEPLETION; GABAERGIC INTERNEURONS; AMYGDALOID STIMULATION;
Keywords:
192 IgG-saporin; hippocampus; cholinergic neurons; noradrenergic neurons; kindling; epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Ferencz, I Univ Lund Hosp, Sect Restorat Neurol, Wallenberg Neurosci Ctr, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 Ctr, S-22185 Lund, Sweden
Citazione:
I. Ferencz et al., "Septal cholinergic neurons suppress seizure development in hippocampal kindling in rats: Comparison with noradrenergic neurons", NEUROSCIENC, 102(4), 2001, pp. 819-832

Abstract

Widespread lesions of forebrain cholinergic or noradrenergic projections by intraventricular administration of 192 IgG-saporin or 6-hydroxpdopamine, respectively, accelerate kindling epileptogenesis. Here we demonstrate bothquantitative and qualitative differences between the two lesions in their effects on hippocampal kindling in rats. Epileptogenesis was significantly faster after noradrenergic as compared to cholinergic denervation, and whenboth lesions were combined, kindling development resembled that in animalswith h-hydroxydopamine lesion alone. Furthermore, whereas the 192 IgG-saporin lesion promoted the development only of the early stages of kindling, administration of 6-hydroxy-dopamine or both neurotoxins accelerated the late stages also. To investigate the contribution of different subparts of thebasal forebrain cholinergic system to its seizure-suppressant action in hippocampal kindling. 192 IgG-saporin was injected into medial septum/vertical limb of the diagonal band of Broca or nucleus basalis magnocellularis, leading to selective hippocampal or cortical cholinergic deafferentation, respectively. The denervation of the hippocampus facilitated kindling similar to the extensive lesion caused by intraventricular 192 IgG-saporin, whereasthe cortical lesion had no effect. These results indicate that although both noradrenergic and cholinergic projections to the forebrain exert powerful inhibitory effects on hippocampalkindling epileptogenesis, the action of the cholinergic system is less pronounced and occurs specifically prior to seizure generalization. In contrast. noradrenergic neurons inhibit the development of both focal and generalized seizures. The septo-hippocampal neurons are responsible for the antiepileptogenic effect of the cholinergic system in hippocampal kindling, whereas the cortical projection is not significantly involved, Conversely, we have previously shown [Ferencz I. er nl. (2000) Eur. J. Neurosci., 12, 2107-2116] that seizure-suppression in amygdala kindling is exerted through the cortical and not the hippocampal cholinergic projection. This shows that, depending on the location of the primary epileptic focus, i.e. the site of stimulation, basal forebrain cholinergic neurons operate through different subsystems to counteract seizure development in kindling. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:13:39