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Titolo:
Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons
Autore:
Cossart, R; Tyzio, R; Dinocourt, C; Esclapez, M; Hirsch, JC; Ben-Ari, Y; Bernard, C;
Indirizzi:
INSERM, INMED, U29, F-13273 Marseille, France INSERM Marseille France F-13273 M, INMED, U29, F-13273 Marseille, France Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Div Neurosci, Houston, TX 77030 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 29, anno: 2001,
pagine: 497 - 508
SICI:
0896-6273(200102)29:2<497:PKRTET>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; RAT HIPPOCAMPUS; SYNAPTIC ACTIVATION; IN-VITRO; GABAERGIC INTERNEURONS; TRANSMITTER RELEASE; PYRAMIDAL NEURONS; AMPA RECEPTORS; INHIBITION; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Ben-Ari, Y INSERM, INMED, U29, Parc Sci Luminy,BP 13, F-13273 Marseille, France INSERM Parc Sci Luminy,BP 13 Marseille France F-13273 , France
Citazione:
R. Cossart et al., "Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons", NEURON, 29(2), 2001, pp. 497-508

Abstract

We report that kainate receptors are present on presynaptic GABAergic terminals contacting interneurons and that their activation increases GABA release. Application of kainate increased the frequency of miniature inhibitorypostsynaptic currents recorded in CA1 interneurons. Local applications of glutamate but not of AMPA or NMDA also increased GABA quantal release. Application of kainate as well as synaptically released glutamate reduced the number of failures of GABAergic neurotransmission between interneurons. Thus, activation of presynaptic kainate receptors increases the probability of GABA release at interneuron-interneuron synapses. Glutamate may selectivelycontrol the communication between interneurons by increasing their mutual inhibition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:11:38