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Titolo:
Electrical activity modulates growth cone guidance by diffusible factors
Autore:
Ming, GL; Henley, J; Tessier-Lavigne, M; Song, HJ; Poo, MM;
Indirizzi:
Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 t Biol, La Jolla, CA 92093 USA Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ll Biol, Berkeley, CA 94720 USA Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 29, anno: 2001,
pagine: 441 - 452
SICI:
0896-6273(200102)29:2<441:EAMGCG>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT PROTEIN-KINASE; NERVE GROWTH; NEURITE GROWTH; DIRECTION; ABSENCE; FIELDS; INHIBITION; NETRIN-1; CURRENTS; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Song, HJ Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USASalk Inst Biol Studies La Jolla CA USA 92037 Jolla, CA 92037 USA
Citazione:
G.L. Ming et al., "Electrical activity modulates growth cone guidance by diffusible factors", NEURON, 29(2), 2001, pp. 441-452

Abstract

Brief periods of electrical stimulation of cultured Xenopus spinal neuronsresulted in a marked alteration in the turning responses of the growth cone induced by gradients of attractive or repulsive guidance cues. Netrin-1-induced attraction was enhanced, and the repulsion induced by myelin-associated glycoprotein (MAG) or myelin membrane fragments was converted to attraction. The effect required the presence of extracellular Ca2+ during electrical stimulation and appeared to be mediated by an elevation of both cytoplasmic Ca2+ and cAMP. Thus, electrical activity may influence the axonal pathfinding of developing neurons, and intermittent electrical stimulation maybe effective in promoting nerve regeneration after injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:27:48