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Titolo:
Evx1 is a postmitotic determinant of V0 interneuron identity in the spinalcord
Autore:
Moran-Rivard, L; Kagawa, T; Saueressig, H; Gross, MK; Burill, J; Goulding, M;
Indirizzi:
Salk Inst, Mol Neurobiol Lab, La Jolla, CA 92037 USA Salk Inst La Jolla CA USA 92037 Mol Neurobiol Lab, La Jolla, CA 92037 USA Univ Calif San Diego, Biol Grad Program, La Jolla, CA 92093 USA Univ CalifSan Diego La Jolla CA USA 92093 rogram, La Jolla, CA 92093 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 29, anno: 2001,
pagine: 385 - 399
SICI:
0896-6273(200102)29:2<385:EIAPDO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGENITOR-CELL IDENTITY; MOTOR-NEURON; HOMEODOMAIN PROTEIN; TRANSCRIPTIONAL REPRESSION; COMMISSURAL INTERNEURONS; FLOOR PLATE; GENE; EXPRESSION; MOUSE; SPECIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Goulding, M Salk Inst, Mol Neurobiol Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA Salk Inst 10010 N Torrey Pines Rd La Jolla CA USA 92037 37 USA
Citazione:
L. Moran-Rivard et al., "Evx1 is a postmitotic determinant of V0 interneuron identity in the spinalcord", NEURON, 29(2), 2001, pp. 385-399

Abstract

Interneurons in the ventral spinal cord are essential for coordinated locomotion in vertebrates. During embryogenesis, the V0 and V1 classes of ventral interneurons are defined by expression of the homeodomain transcription factors Evx1/2 and En1, respectively. In this study, we show that Evx1 V0 interneurons are locally projecting intersegmental commissural neurons. In Evx1 mutant embryos, the majority of V0 interneurons fail to extend commissural axons. Instead, they adopt an En1-like ipsilateral axonal projection and ectopically express En1, indicating that V0 interneurons are transfated to a V1 identity. Conversely, misexpression of Evx1 represses En1, suggesting that Evx1 may suppress the V1 interneuron differentiation program. Our findings demonstrate that Evx1 is a postmitotic determinant of V0 interneuronidentity and reveal a critical postmitotic phase for neuronal determination in the developing spinal cord.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:37:16