Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A genetic analysis of neural progenitor differentiation
Autore:
Geschwind, DH; Ou, J; Easterday, MC; Dougherty, JD; Jackson, RL; Chen, ZG; Antoine, H; Terskikh, A; Weissman, IL; Nelson, SF; Kornblum, HI;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Neurogenet Program, Los Angeles, CA 90095USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095USA Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA90095 USA Univ Calif Los Angeles, Sch Med, Dept Pediat, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Crump Inst Mol Imaging, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Sch Med, Mental Retardat Res Ctr, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA Stanford UnivStanford CA USA 94305 , Dept Pathol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Dept Dev Biol, Stanford, CA 94305 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 29, anno: 2001,
pagine: 325 - 339
SICI:
0896-6273(200102)29:2<325:AGAONP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; EPIDERMAL GROWTH-FACTOR; HEMATOPOIETIC STEM-CELLS; FYN TYROSINE KINASE; SIGNALING PATHWAY; CYCLE KINETICS; GERMINAL ZONE; MESSENGER-RNA; EXPRESSION; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Geschwind, DH Univ Calif Los Angeles, Sch Med, Neurogenet Program, Los Angeles, CA 90095USA Univ Calif Los Angeles Los Angeles CA USA 90095 CA 90095USA
Citazione:
D.H. Geschwind et al., "A genetic analysis of neural progenitor differentiation", NEURON, 29(2), 2001, pp. 325-339

Abstract

Genetic mechanisms regulating CNS progenitor function and differentiation are not well understood. We have used microarrays derived from a representational difference analysis (RDA) subtraction in a heterogeneous stem cell culture system to systematically study the gene expression patterns of CNS progenitors. This analysis identified both known and novel genes enriched inprogenitor cultures. In situ hybridization in a subset of clones demonstrated that many of these genes were expressed preferentially in germinal zones, some showing distinct ventricular or subventricular zone labeling. Several genes were also enriched in hematopoietic stem cells, suggesting an overlap of gene expression in neural and hematopoietic progenitors. This combination of methods demonstrates the power of using custom microarrays derivedfrom RDA-subtracted libraries for both gene discovery and gene expression analysis in the central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:34:02