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Titolo:
Incidence and risk factors in sudden unexpected death in epilepsy - A prospective cohort study
Autore:
Walczak, TS; Leppik, IE; DAmelio, M; Rarick, J; So, E; Ahman, P; Ruggles, K; Cascino, GD; Annegers, JF; Hauser, WA;
Indirizzi:
MINCEP Epilepsy Care, Minneapolis, MN 55416 USA MINCEP Epilepsy Care Minneapolis MN USA 55416 , Minneapolis, MN 55416 USA Univ Minnesota, Dept Expt & Clin Pharmacol, Minneapolis, MN USA Univ Minnesota Minneapolis MN USA & Clin Pharmacol, Minneapolis, MN USA Columbia Univ Coll Phys & Surg, GH Sergievski Ctr, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Mayo Clin, Epilepsy Div, Dept Neurol, Rochester, MN USA Mayo Clin Rochester MN USA Epilepsy Div, Dept Neurol, Rochester, MN USA Marshfield Clin, Dept Neurol, Marshfield, WI USA Marshfield Clin Marshfield WI USA Clin, Dept Neurol, Marshfield, WI USA Univ Texas, Sch Publ Hlth, Dept Epidemiol, Houston, TX USA Univ Texas Houston TX USA Sch Publ Hlth, Dept Epidemiol, Houston, TX USA
Titolo Testata:
NEUROLOGY
fascicolo: 4, volume: 56, anno: 2001,
pagine: 519 - 525
SICI:
0028-3878(20010227)56:4<519:IARFIS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIEPILEPTIC DRUG LEVELS; UNEXPLAINED DEATH; CENTRAL APNEA; SHEEP MODEL; MORTALITY; CARBAMAZEPINE; SEIZURES; PROGRAM; SUDEP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Walczak, TS MINCEP Epilepsy Care, 5775 Wayzata Blvd,Suite 255, Minneapolis, MN 55416 USA MINCEP Epilepsy Care 5775 Wayzata Blvd,Suite 255 MinneapolisMN USA 55416
Citazione:
T.S. Walczak et al., "Incidence and risk factors in sudden unexpected death in epilepsy - A prospective cohort study", NEUROLOGY, 56(4), 2001, pp. 519-525

Abstract

Objective: To determine incidence of and risk factors for sudden unexpected death in epilepsy (SUDEP). Methods: Three epilepsy centers enrolled 4,578patients and prospectively followed these patients for 16,463 patient-years. The cohort was screened for death annually. Deaths were investigated to determine whether SUDEP occurred. Potential risk factors were compared in SUDEP cases and in controls enrolled contemporaneously at the same center. Results: Incidence of SUDEP was 1.21/1,000 patient-years and was higher among women (1.45/1,000) than men (0.98/1,000). SUDEP accounted for 18% of all deaths. Occurrence of tonic-clonic seizures, treatment with more than two anticonvulsant medications, and full-scale IQ less than 70 were independent risk factors for SUDEP. The number of tonic-clonic seizures was a risk factor only in women. The presence of cerebral structural lesions and use of psychotropic drugs at the last visit were not risk factors for SUDEP in this cohort. Subtherapeutic anticonvulsant levels at the last visit were equallycommon in the two groups. No particular anticonvulsant appeared to be associated with SUDEP. Conclusions: These results support the idea that tonic-clonic seizures are an important proximate cause of SUDEP. This information creates a risk profile for SUDEP that may help direct preventative efforts.

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Documento generato il 25/09/20 alle ore 00:39:38