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Titolo:
Functional neuroanatomy of auditory working memory in schizophrenia: Relation to positive and negative symptoms
Autore:
Menon, V; Anagnoson, RT; Mathalon, DH; Glover, GH; Pfefferbaum, A;
Indirizzi:
Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 t & Behav Sci, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA Stanford UnivStanford CA USA 94305 , Dept Radiol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Program Neurosci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 gram Neurosci, Stanford, CA 94305 USA VA Palo Alto Hth Care Syst, Palo Alto, CA 94304 USA VA Palo Alto Hth Care Syst Palo Alto CA USA 94304 Palo Alto, CA 94304 USA SRI Int, Menlo Park, CA 94025 USA SRI Int Menlo Park CA USA 94025SRI Int, Menlo Park, CA 94025 USA
Titolo Testata:
NEUROIMAGE
fascicolo: 3, volume: 13, anno: 2001,
pagine: 433 - 446
SICI:
1053-8119(200103)13:3<433:FNOAWM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FMRI TIME-SERIES; EMISSION COMPUTED-TOMOGRAPHY; PSYCHIATRIC RATING-SCALE; PREFRONTAL CORTEX; PARIETAL CORTEX; BRAIN ACTIVATION; THOUGHT-DISORDER; FRONTAL LOBES; RHESUS-MONKEY; TEMPORAL-LOBE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Menon, V Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Sci, Stanford, CA 94305 USA
Citazione:
V. Menon et al., "Functional neuroanatomy of auditory working memory in schizophrenia: Relation to positive and negative symptoms", NEUROIMAGE, 13(3), 2001, pp. 433-446

Abstract

Functional brain imaging studies of working memory (WM) in schizophrenia have yielded inconsistent results regarding deficits in the dorsolateral prefrontal (DLPFC) and parietal cortices. In spite of its potential importancein schizophrenia, there have been few investigations of WM deficits using auditory stimuli and no functional imaging studies have attempted to relatebrain activation during auditory WM to positive and negative symptoms of schizophrenia. We used a two-back auditory WM paradigm in a functional MRI study of men with schizophrenia (N = 11) and controls (N = 13). Region of interest analysis was used to investigate group differences in activation as well as correlations with symptom scores from the Brief Psychiatric Rating Scale. Patients with schizophrenia performed significantly worse and were slower than control subjects in the WM task. Patients also showed decreased lateralization of activation and significant WM related activation deficitsin the left and right DLPFC, frontal operculum, inferior parietal, and superior parietal cortex but not in the anterior cingulate or superior temporal gyrus. These results indicate that in addition to the prefrontal cortex, parietal cortex function is also disrupted during WM in schizophrenia. Withdrawal-retardation symptom scores were inversely correlated with frontal operculum activation. Thinking disturbance symptom scores were inversely correlated with right DLPFC activation. Our findings suggest an association between thinking disturbance symptoms, particularly unusual thought content, and disrupted WM processing in schizophrenia. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:21:23