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Titolo:
Motilin receptor density in inflamed and noninflamed tissue in rabbit TNBS-induced colitis
Autore:
Depoortere, I; Van Assche, G; Peeters, TL;
Indirizzi:
Univ Leuven, Ctr Gastroenterol Res, Dept Pathophysiol, B-3000 Louvain, Belgium Univ Leuven Louvain Belgium B-3000 Pathophysiol, B-3000 Louvain, Belgium
Titolo Testata:
NEUROGASTROENTEROLOGY AND MOTILITY
fascicolo: 1, volume: 13, anno: 2001,
pagine: 55 - 63
SICI:
1350-1925(200102)13:1<55:MRDIIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; VASOACTIVE INTESTINAL POLYPEPTIDE; ULCERATIVE-COLITIS; SUBSTANCE-P; CROHNS-DISEASE; BINDING-SITES; SMOOTH-MUSCLE; SOMATOSTATIN; ANTAGONIST; PEPTIDE;
Keywords:
contractility; motilin mRNA expression; motilin receptor density; mucosal motilin content; TNBS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Peeters, TL Gasthuisberg O&N, Gut Hormone Lab, Herestr 49, B-3000 Louvain,Belgium Gasthuisberg O&N Herestr 49 Louvain Belgium B-3000 n, Belgium
Citazione:
I. Depoortere et al., "Motilin receptor density in inflamed and noninflamed tissue in rabbit TNBS-induced colitis", NEUROG MOT, 13(1), 2001, pp. 55-63

Abstract

Trinitrobenzenesulphonic acid (TNBS)-induced colitis decreases the contractile response of the rabbit colon to motilin, and inflammation may increaseplasma motilin levels. We studied whether the decreased contractility could be due to a down-regulation of motilin receptors, caused by increased plasma motilin levels. As this would affect all tissues, uninflamed sites werestudied as well. Colitis was induced by different doses (100-150 mg kg(-1)) of TNBS. In the colon, the TNBS dose-dependent decrease of the contractile response towards motilin was reflected in a decrease in motilin receptor density. In contrast, in the antrum, receptors were upregulated by 150 mg kg(-1) TNBS, while central motilin receptors in the cerebellum were not affected. Plasma motilin levels were not influenced by inflammation, although the motilin content and mRNA expression in the duodenal and jejunal mucosa, but not in the colon, was significantly increased. The opposite was true for interleukin-1 beta and interleukin receptor antagonist mRNA expression. We conclude that the decreased motilin contractility in rabbit colitis is due to a downregulation of motilin receptors in the colon, but this is not caused by chronic hormonal stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:34:37