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Titolo:
Aging affects transcranial magnetic modulation of hippocampal evoked potentials
Autore:
Levkovitz, Y; Segal, M;
Indirizzi:
Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 biol, IL-76100 Rehovot, Israel
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 2, volume: 22, anno: 2001,
pagine: 255 - 263
SICI:
0197-4580(200103/04)22:2<255:AATMMO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECURRENT MAJOR DEPRESSION; AFFERENT STIMULATION; 5-HT1A RECEPTORS; BINDING-SITES; AGED RATS; BRAIN; MONOAMINES; REACTIVITY; NERVE;
Keywords:
transcranial magnetic stimulation; aging rats; dentate gyrus; serotonin; LTP; GABAergic inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Segal, M Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 76100 Rehovot, Israel
Citazione:
Y. Levkovitz e M. Segal, "Aging affects transcranial magnetic modulation of hippocampal evoked potentials", NEUROBIOL A, 22(2), 2001, pp. 255-263

Abstract

Transcranial magnetic stimulation (TMS) is being proposed as a method of choice for the treatment of clinical depression, yet its action in the brainis still not well understood. In previous studies we found that TMS has a long-term effect on reactivity of the hippocampus to perforant path stimulation. Since the efficacy of antidepressants is highly age-dependent, we studied possible age-related effects of TMS on hippocampal evoked responses. Young adult (3 months), aging (10 months) and aged (24-26 months) awake ratswere subjected to daily TMS for one week, followed by measurements of several parameters of reactivity to perforant path stimulation in the anesthetized rat. TMS did not affect responses of the hippocampus to single perforant path stimulation, but reduced drastically paired-pulse and frequency dependent depression in the young and aging but not the old rats. Likewise, TMSincreased LTP expression in the young but not the old rats, and reduced the efficacy of serotonin modulation of reactivity of the hippocampus, in theyoung but not the old rats. Thus, long term effects of chronic TMS on local GABAergic inhibition are highly age dependent. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:15:05