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Titolo:
Interactions of prefrontal cortex during eyeblink conditioning as a function of age
Autore:
Schreurs, BG; Bahro, M; Molchan, SE; Sunderland, T; McIntosh, AR;
Indirizzi:
NINDS, Behav Neurol Unit, Lab Adapt Syst, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 Unit, Lab Adapt Syst, Bethesda, MD 20892 USA Univ Bern, Geriatr Psychiat Dept, CH-3072 Ostermundigen Berne, SwitzerlandUniv Bern Ostermundigen Berne Switzerland CH-3072 gen Berne, Switzerland NIMH, Geriatr Psychiat Branch, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 eriatr Psychiat Branch, Bethesda, MD 20892 USA Univ Toronto, Baycrest Ctr, Rotman Res Inst, Toronto, ON M6A 2E1, Canada Univ Toronto Toronto ON Canada M6A 2E1 Inst, Toronto, ON M6A 2E1, Canada
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 2, volume: 22, anno: 2001,
pagine: 237 - 246
SICI:
0197-4580(200103/04)22:2<237:IOPCDE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; WORKING-MEMORY; FRONTAL-CORTEX; PET IMAGES; BRAIN; ACTIVATION; LESIONS; HUMANS; MOTOR;
Keywords:
positron emission tomography; eyeblink conditioning; aging; prefrontal cortex; functional connectivity; regional cerebral blood flow; cerebellum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Schreurs, BG W Virginia Univ, Dept Physiol, POB 9300, Morgantown, WV 26506USA W Virginia Univ POB 9300 Morgantown WV USA 26506 WV 26506 USA
Citazione:
B.G. Schreurs et al., "Interactions of prefrontal cortex during eyeblink conditioning as a function of age", NEUROBIOL A, 22(2), 2001, pp. 237-246

Abstract

Changes in regional cerebral blood flow (rCBF) in eleven elderly subjects during pairings of tone and air puff were compared to rCBF changes during pairings in young subjects. Although all subjects reported being aware of the relationship between tone and air puff, elderly subjects did not condition as well as young subjects and their rCBF measures were attenuated. Covarying the performance differences between young and old subjects did not change this conclusion suggesting that differences in neural activation during learning are related to binding of CS-US information prior to the impact ofthe association on performance. Both groups showed learning-specific rCBF changes in cerebellum, inferior right prefrontal cortex and posterior cingulate. However, only in young subjects were there learning-specific changes in rCBF in left temporal cortex, midbrain, caudate, and inferior left prefrontal cortex. Analysis of learning-dependent patterns of functional connectivity of inferior left prefrontal cortex showed only young subjects had a strong left prefrontal functional connectivity with cerebellum, hippocampus,thalamus and temporal cortex. Thus, beyond changes in regional activity, these data also suggest that age may alter the operations of functional networks underlying learning and memory. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 30/03/20 alle ore 19:56:26