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Titolo:
Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice
Autore:
De Sarro, G; Di Paola, ED; Conte, G; Pasculli, MP; De Sarro, A;
Indirizzi:
Univ Catanzaro, Fac Med & Surg, Policlin Mater Domini, Dept Expt & Clin Med,Chair Pharmacol, I-88100 Catanzaro, Italy Univ Catanzaro Catanzaro Italy I-88100 armacol, I-88100 Catanzaro, Italy Univ Messina, Fac Med & Surg, Inst Pharmacol, Chair Chemotherapy, Messina,Italy Univ Messina Messina Italy Pharmacol, Chair Chemotherapy, Messina,Italy
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 3, volume: 363, anno: 2001,
pagine: 330 - 336
SICI:
0028-1298(200103)363:3<330:IOROTA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT ENTORHINAL CORTEX; INDUCED EPILEPTIFORM ACTIVITY; HIPPOCAMPUS IN-VITRO; ANTISEIZURE ACTIVITY; DIFFERENT PATTERNS; LOW MAGNESIUM; D-23129; SLICES; 4-AMINOPYRIDINE; GLUCURONIDATION;
Keywords:
epilepsy; retigabine; carbamazepine; phenytoin; valproate; felbamate; anticonvulsants; audiogenic seizures; DBA/2 mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: De Sarro, G Univ Catanzaro, Fac Med & Surg, Policlin Mater Domini, Dept Expt & Clin Med,Chair Pharmacol, Via T Campanella 115, I-88100 Catanzaro, Italy Univ Catanzaro Via T Campanella 115 Catanzaro Italy I-88100 y
Citazione:
G. De Sarro et al., "Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice", N-S ARCH PH, 363(3), 2001, pp. 330-336

Abstract

Retigabine (D-2319, 0.5-20 mg/kg i.p.) antagonised dose dependently audiogenic seizures in DBA/2 mice. Retigabine at 0.5 mg/kg i.p., a dose that per se did not affect the occurrence of audiogenic seizures significantly, potentiated the anticonvulsant activity of carbamazepine, diazepam, felbamate, lamotrigine, phenytoin, phenobarbital and valproate against sound-induced seizures in DBA/2 mice. The degree of additivity for the effect induced by retigabine was greatest for diazepam, phenobarbital, phenytoin and valproate, less for carbamazepine and lamotrigine and least for felbamate. The increase in anticonvulsant activity was usually associated with a comparable increase in motor impairment. However, the therapeutic index of combined treatment (drugs plus retigabine), was more favourable than the same drug plus vehicle. Since retigabine had no significant influence on the total and freeplasma levels of the anticonvulsant drugs, pharmacokinetic interactions, in terms of total or free plasma levels, are not probable. However, the possibility that retigabine modifies the clearance of the anticonvulsant drugs from the brain cannot be excluded. Retigabine had no significant effect on the hypothermic effects of the anticonvulsants tested. In conclusion, retigabine showed an additive effect when administered in combination with classical anticonvulsants, most notably diazepam, phenobarbital, phenytoin and valproate.

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Documento generato il 09/04/20 alle ore 07:38:08