Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Regulatory role of nitric oxide over hippocampal 5-HT release in vivo
Autore:
Segieth, J; Pearce, B; Fowler, L; Whitton, PS;
Indirizzi:
Univ London, Sch Pharm, Dept Pharmacol, London WC1N 1AX, England Univ London London England WC1N 1AX Pharmacol, London WC1N 1AX, England
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 3, volume: 363, anno: 2001,
pagine: 302 - 306
SICI:
0028-1298(200103)363:3<302:RRONOO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR 5-HYDROXYTRYPTAMINE CONCENTRATION; LONG-TERM POTENTIATION; FREELY MOVING RATS; STRIATUM IN-VIVO; SYNTHASE INHIBITOR; INDUCED SEIZURES; RAPHE NUCLEI; SEROTONIN; INCREASES; DOPAMINE;
Keywords:
5-hydroxytryptamine; nitric oxide; nitric oxide synthase inhibitors; hippocampus; dialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Whitton, PS Univ London, Sch Pharm, Dept Pharmacol, 29-39 Brunswick Sq, London WC1N 1AX, England Univ London 29-39 Brunswick Sq London England WC1N 1AX ngland
Citazione:
J. Segieth et al., "Regulatory role of nitric oxide over hippocampal 5-HT release in vivo", N-S ARCH PH, 363(3), 2001, pp. 302-306

Abstract

Previous work has shown that N-methyl-D-aspartate (NMDA) receptor activation decreases 5-hydroxytryptamine (5-HT) release in the hippocampus of freely moving rats. Given the association between NMDA receptor function and nitric oxide (NO) production with the regulation of 5-HT release in other brain regions, we have studied this in rat hippocampus. NMDA (100 muM) decreased hippocampal 5-HT release by approximately 70% and this was reversed by the NMDA receptor antagonist 2-amino-5-phosphonopentanoic acid (AP5; 10 muM). The NO donor S-nitroso-N-acetylpenicillamine (SNAP) had an inverse concentration-dependent effect on 5-HT release. At 500 muM, SNAP elevated dialysate 5-HT by 55% over basal, while at 5 mM a 70% decrease was seen. The non-selective nitric oxide synthase (NOS) inhibitor N-nitro-L-arginine methyl ester (L-NAME) at 1 mM increased extracellular 5-HT, although a return to basal levels occurred despite the continued presence of the drug. At 1 mM L-NAME prevented the decrease in 5-HT elicited by NMDA (100 muM) infusion. 7-Nitroindazole (7-NI), a relatively selective neuronal NOS (nNOS) inhibitor, decreased extracellular 5-HT at 100 CIM and 1 mM. When 100 CIM 7-NI was infused for 60 min prior to NMDA, 5-HT levels were transiently increased above basal before returning to control levels. Following combined application of the two drugs, no decrease in dialysate 5-HT was seen. Our data support a role for NO in modulating both basal and NMDA-evoked changes in 5-HT releasein the hippocampus, however, the association appears to be complex. It maybe that the recorded changes in 5-HT release are secondary to changes in the release of amino acid transmitters which we have previously found to be dependent on the prevailing extracellular NO concentration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:20:27