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Titolo:
Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A
Autore:
Deken, SL; Beckman, ML; Boos, L; Quick, MW;
Indirizzi:
Univ Alabama, Dept Neurobiol, CIRC 446, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 , CIRC 446, Birmingham, AL 35294 USA Univ Alabama, Med Sci Training Program, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ng Program, Birmingham, AL 35294 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 10, volume: 3, anno: 2000,
pagine: 998 - 1003
SICI:
1097-6256(200010)3:10<998:TROGTR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-PROTEIN INTERACTIONS; CELL-SURFACE EXPRESSION; CFTR CHLORIDE CHANNELS; FUNCTIONAL REGULATION; RECEPTORS; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Quick, MW Univ Alabama, Dept Neurobiol, CIRC 446, 1719 6th Ave S, Birmingham, AL 35294 USA Univ Alabama 1719 6th Ave S Birmingham AL USA 35294 AL 35294 USA
Citazione:
S.L. Deken et al., "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A", NAT NEUROSC, 3(10), 2000, pp. 998-1003

Abstract

Plasma membrane GABA transporters participate in neural signaling through re-uptake of neurotransmitter. The domains of the transporter that mediate GABA translocation and regulate transport are not well understood. In the present experiments, the N-terminal cytoplasmic domain of the GABA transporter GAT1 regulated substrate transport rates. This domain directly interacted with syntaxin 1A, a SNARE protein involved in both neurotransmitter release and modulation of calcium channels and cystic fibrosis transmembrane regulator (CFTR) chloride channels. The interaction resulted in a decrease in transporter transport rates. These data demonstrate that intracellular domains of the GABA and protein-protein interactions regulate substrate translocation, and identify a direct link between the machinery involved in transmitter release and re-uptake.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:54:33