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Titolo:
Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients
Autore:
Llano, I; Gonzalez, J; Caputo, C; Lai, FA; Blayney, LM; Tan, YP; Marty, A;
Indirizzi:
Max Planck Inst Biophys Chem, Arbeitsgrp Zellulare Neurobiol, D-37077 Gottingen, Germany Max Planck Inst Biophys Chem Gottingen Germany D-37077 ottingen, Germany Inst Venezolano Invest Cient, Ctr Biofis, Caracas 1020A, Venezuela Inst Venezolano Invest Cient Caracas Venezuela 1020A as 1020A, Venezuela Univ Wales, Div Med Cardiol, Cardiff CF4 4XN, S Glam, Wales Univ Wales Cardiff S Glam Wales CF4 4XN l, Cardiff CF4 4XN, S Glam, Wales Bogazici Univ, Istanbul, Turkey Bogazici Univ Istanbul TurkeyBogazici Univ, Istanbul, Turkey
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 12, volume: 3, anno: 2000,
pagine: 1256 - 1265
SICI:
1097-6256(200012)3:12<1256:PCSULM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR PURKINJE-CELLS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; CENTRAL-NERVOUS-SYSTEM; CA2+ RELEASE CHANNELS; SKELETAL-MUSCLE; SYNAPTIC TRANSMISSION; RYANODINE RECEPTOR; IMMUNOHISTOCHEMICAL LOCALIZATION; NEUROTRANSMITTER RELEASE; HIPPOCAMPAL-NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Llano, I Max Planck Inst Biophys Chem, Arbeitsgrp Zellulare Neurobiol, D-37077 Gottingen, Germany Max Planck Inst Biophys Chem Gottingen Germany D-37077 Germany
Citazione:
I. Llano et al., "Presynaptic calcium stores underlie large-amplitude miniature IPSCs and spontaneous calcium transients", NAT NEUROSC, 3(12), 2000, pp. 1256-1265

Abstract

The cellular mechanisms responsible for large miniature currents in some brain synapses remain undefined. In Purkinje cells, we found that large-amplitude miniature inhibitory postsynaptic currents (mIPSCs) were inhibited byryanodine or by long-term removal of extracellular Ca2+. Two-photon Ca2+ imaging revealed random, ryanodine-sensitive intracellular Ca2+ transients, spatially constrained at putative presynaptic terminals. At high concentration, ryanodine decreased action-potential-evoked rises in intracellular Ca2. Immuno-localization showed ryanodine receptors in these terminals. Our data suggest that large mIPSCs are multivesicular events regulated by Ca2+ release from ryanodine-sensitive presynaptic Ca2+ stores.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:52:02