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Titolo:
Glutamate receptors regulate actin-based plasticity in dendritic spines
Autore:
Fischer, M; Kaech, S; Wagner, U; Brinkhaus, H; Matus, A;
Indirizzi:
Friedrich Miescher Inst, CH-4002 Basel, Switzerland Friedrich Miescher Inst Basel Switzerland CH-4002 002 Basel, Switzerland
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 9, volume: 3, anno: 2000,
pagine: 887 - 894
SICI:
1097-6256(200009)3:9<887:GRRAPI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY POSTSYNAPTIC POTENTIALS; EXPERIENCE-DEPENDENT PLASTICITY; CENTRAL-NERVOUS-SYSTEM; AMPA RECEPTORS; HIPPOCAMPAL-NEURONS; PYRAMIDAL NEURONS; CA2+ PERMEABILITY; CALCIUM CHANNELS; SINGLE SPINES; SYNAPSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Matus, A Friedrich Miescher Inst, POB 2543, CH-4002 Basel, Switzerland Friedrich Miescher Inst POB 2543 Basel Switzerland CH-4002 rland
Citazione:
M. Fischer et al., "Glutamate receptors regulate actin-based plasticity in dendritic spines", NAT NEUROSC, 3(9), 2000, pp. 887-894

Abstract

Dendritic spines at excitatory synapses undergo rapid, actin-dependent shape changes which may contribute to plasticity in brain circuits. Here we show that actin dynamics in spines are potently inhibited by activation of either AMPA or NMDA subtype glutamate receptors. Activation of either receptor type inhibited actin-based protrusive activity from the spine head. This blockade of motility caused spines to round up so that spine morphology became both more stable and more regular. Inhibition of spine motility by AMPAreceptors was dependent on postsynaptic membrane depolarization and influxof Ca2+ through voltage-activated channels. In combination with previous studies, our results suggest a two-step process in which spines initially formed in response to NMDA receptor activation are subsequently stabilized byAMPA receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 09:50:31