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Titolo:
Dendritic coincidence detection of EPSDs and action potentials
Autore:
Stuart, GJ; Hausser, M;
Indirizzi:
Australian Natl Univ, John Curtin Sch Med Res, Div Neurosci, Canberra, ACT0200, Australia Australian Natl Univ Canberra ACT Australia 0200 erra, ACT0200, Australia Univ London Univ Coll, Dept Physiol, London WC1E 6BT, England Univ London Univ Coll London England WC1E 6BT , London WC1E 6BT, England
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 1, volume: 4, anno: 2001,
pagine: 63 - 71
SICI:
1097-6256(200101)4:1<63:DCDOEA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEOCORTICAL PYRAMIDAL NEURONS; TERM SYNAPTIC PLASTICITY; EXCITATORY POSTSYNAPTIC POTENTIALS; RABBIT FOLLOWING STIMULATION; LONG-LASTING POTENTIATION; HIPPOCAMPAL-NEURONS; PERFORANT PATH; NMDA RECEPTORS; CALCIUM INFLUX; DENTATE AREA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Stuart, GJ Australian Natl Univ, John Curtin Sch Med Res, Div Neurosci, Canberra, ACT0200, Australia Australian Natl Univ Canberra ACT Australia 0200 00, Australia
Citazione:
G.J. Stuart e M. Hausser, "Dendritic coincidence detection of EPSDs and action potentials", NAT NEUROSC, 4(1), 2001, pp. 63-71

Abstract

We describe a mechanism for coincidence detection mediated by the interaction between backpropagating action potentials and EPSPs in neocortical pyramidal neurons. At distal dendritic locations, appropriately timed EPSPs or oscillations could increase the amplitude of backpropagating action potentials by three- to fourfold. This amplification was greatest when action potentials occurred at the peak of EPSPs or dendritic oscillations and could lead to somatic burst firing. The increase in amplitude required sodium channel activation but not potassium channel inactivation. The temporal characteristics of this amplification are similar to those required for changes in synaptic strength, suggesting that this mechanism may be involved in the induction of synaptic plasticity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 10:40:19