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Titolo:
Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy
Autore:
Cossart, R; Dinocourt, C; Hirsch, JC; Merchan-Perez, A; De Felipe, J; Ben-Ari, Y; Esclapez, M; Bernard, C;
Indirizzi:
INSERM, U29, INMED, F-13273 Marseille 09, France INSERM Marseille France09 ERM, U29, INMED, F-13273 Marseille 09, France CSIC, Inst Cajal, E-28002 Madrid, Spain CSIC Madrid Spain E-28002CSIC, Inst Cajal, E-28002 Madrid, Spain
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 1, volume: 4, anno: 2001,
pagine: 52 - 62
SICI:
1097-6256(200101)4:1<52:DBNSGI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; GAMMA-AMINOBUTYRIC-ACID; CA1 PYRAMIDAL NEURONS; STRATUM-ORIENS-ALVEUS; RAT HIPPOCAMPUS; GLUTAMATE-DECARBOXYLASE; SELECTIVE LOSS; DENTATE GYRUS; 2 FORMS; POSTSYNAPTIC CURRENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Ben-Ari, Y INSERM, U29, INMED, Ave Luminy,BP 13, F-13273 Marseille 09, France INSERM Ave Luminy,BP 13 Marseille France 09 rseille 09, France
Citazione:
R. Cossart et al., "Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy", NAT NEUROSC, 4(1), 2001, pp. 52-62

Abstract

Impaired inhibition is thought to be important in temporal lobe epilepsy (TLE), the most common form of epilepsy in adult patients. We report that, in experimental TLE, spontaneous GABAergic inhibition was increased in the soma but reduced in the dendrites of pyramidal neurons. The former resulted from the hyperactivity of somatic projecting interneurons, whereas the latter was probably due to the degeneration of a subpopulation of dendritic projecting interneurons. A deficit in dendritic inhibition could reduce seizure threshold, whereas enhanced somatic inhibition would prevent the continuous occurrence of epileptiform activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:58:54