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Titolo:
Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons
Autore:
Bomze, HM; Bulsara, KR; Iskandar, BJ; Caroni, P; Skene, JHP;
Indirizzi:
Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA Duke Univ DurhamNC USA 27710 d Ctr, Dept Neurobiol, Durham, NC 27710 USA Duke Univ, Med Ctr, Div Neurosurg, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 ed Ctr, Div Neurosurg, Durham, NC 27710 USA Univ Wisconsin, Dept Neurol Surg, Madison, WI 53792 USA Univ Wisconsin Madison WI USA 53792 pt Neurol Surg, Madison, WI 53792 USA Friedrich Miescher Inst, CH-4058 Basel, Switzerland Friedrich Miescher Inst Basel Switzerland CH-4058 058 Basel, Switzerland
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 1, volume: 4, anno: 2001,
pagine: 38 - 43
SICI:
1097-6256(200101)4:1<38:SAREBR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SENSORY NEURONS; CENTRAL-NERVOUS-SYSTEM; NEURITE OUTGROWTH; PERIPHERAL-NERVE; CORTICOSPINAL TRACT; FUNCTIONAL RECOVERY; GAP-43 EXPRESSION; MESSENGER-RNAS; GANGLION-CELLS; MAMMALIAN CNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Skene, JHP Duke Univ, Med Ctr, Dept Neurobiol, Bryan Res Bldg, Durham, NC 27710 USA Duke Univ Bryan Res Bldg Durham NC USA 27710 rham, NC 27710 USA
Citazione:
H.M. Bomze et al., "Spinal axon regeneration evoked by replacing two growth cone proteins in adult neurons", NAT NEUROSC, 4(1), 2001, pp. 38-43

Abstract

In contrast to peripheral nerves, damaged axons in the mammalian brain andspinal cord rarely regenerate. Peripheral nerve injury stimulates neuronalexpression of many genes that are not generally induced by CNS lesions, but it is not known which of these genes are required for regeneration. Here we show that co-expressing two major growth cone proteins, GAP-43 and GAP-23, can elicit long axon extension by adult dorsal root ganglion (DRG) neurons in vitro. Moreover, this expression triggers a 60-fold increase in regeneration of DRG axons in adult mice after spinal cord injury in vivo. Replacing key growth cone components, therefore, could be an effective way to stimulate regeneration of CNS axons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:41:54