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Titolo:
In vivo intracellular recording and perturbation of persistent activity ina neural integrator
Autore:
Aksay, E; Gamkrelidze, G; Seung, HS; Baker, R; Tank, DW;
Indirizzi:
Bell Labs, Lucent Technol, Biol Computat Res Dept, Murray Hill, NJ 07974 USA Bell Labs Murray Hill NJ USA 07974 at Res Dept, Murray Hill, NJ 07974 USA NYU, Sch Med, Dept Physiol & Neurosci, New York, NY 10016 USA NYU New York NY USA 10016 Dept Physiol & Neurosci, New York, NY 10016 USA MIT, Howard Hughes Med Inst, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 pt Brain & Cognit Sci, Cambridge, MA 02139 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 2, volume: 4, anno: 2001,
pagine: 184 - 193
SICI:
1097-6256(200102)4:2<184:IVIRAP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EYE-POSITION; BRAIN-STEM; PLATEAU POTENTIALS; OCULOMOTOR SYSTEM; PYRAMIDAL NEURONS; MOTOR-NEURONS; ALERT CAT; MEMORY; MOVEMENTS; GOLDFISH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Baker, R Bell Labs, Lucent Technol, Biol Computat Res Dept, 700 Mt Ave, Murray Hill, NJ 07974 USA Bell Labs 700 Mt Ave Murray Hill NJ USA 07974 Hill, NJ 07974 USA
Citazione:
E. Aksay et al., "In vivo intracellular recording and perturbation of persistent activity ina neural integrator", NAT NEUROSC, 4(2), 2001, pp. 184-193

Abstract

To investigate the mechanisms of persistent neural activity, we obtained in vivo intracellular recordings from neurons in an oculomotor neural integrator of the goldfish during spontaneous saccades and fixations. Persistent changes in firing rate following saccades were associated with step changesin interspike membrane potential that were correlated with changes in eye position. Perturbation of persistent activity with brief intracellular current pulses designed to mimic saccadic input only induced transient changes of firing rate and membrane potential. When neurons were hyperpolarized below action potential threshold, position-correlated step changes in membranepotential remained. Membrane potential fluctuations were greater during more depolarized steps. These results suggest that sustained changes in firing rate are supported not by either membrane multistability or changes in pacemaker currents, but rather by persistent changes in the rate or amplitudeof synaptic inputs.

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Documento generato il 03/04/20 alle ore 08:05:27