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Titolo:
Cyclic AMP-dependent protein kinase mediates ocular dominance shifts in cat visual cortex
Autore:
Beaver, CJ; Ti, QH; Fischer, QS; Daw, NW;
Indirizzi:
Yale Univ, Sch Med, Dept Ophthalmol & Visual Sci, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ol & Visual Sci, New Haven, CT 06520 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 2, volume: 4, anno: 2001,
pagine: 159 - 163
SICI:
1097-6256(200102)4:2<159:CAPKMO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; NITRIC-OXIDE SYNTHASE; HIPPOCAMPAL-NEURONS; CRITICAL PERIOD; MONOCULAR DEPRIVATION; GLUTAMATE RECEPTORS; ADENYLATE-CYCLASE; CAMP LEVELS; LATE-PHASE; IN-VITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Beaver, CJ Yale Univ, Sch Med, Dept Ophthalmol & Visual Sci, 333 Cedar St,New Haven,CT 06520 USA Yale Univ 333 Cedar St New Haven CT USA 06520 aven,CT 06520 USA
Citazione:
C.J. Beaver et al., "Cyclic AMP-dependent protein kinase mediates ocular dominance shifts in cat visual cortex", NAT NEUROSC, 4(2), 2001, pp. 159-163

Abstract

Visual experience during a critical period early in postnatal development can change connections within mammalian visual cortex. In a kitten at the peak of the critical period (similar to P28-42), brief monocular deprivationcan lead to complete dominance by the open eye, an ocular dominance shift. This process is driven by activity from the eyes, and depends on N-methyl-D-aspartate (NMDA) receptor activation. The components of the intracellularsignaling cascade underlying these changes have not all been identified. Here we show that inhibition of protein kinase A (PKA) by Rp-8-C1-cAMPS blocks ocular dominance shifts that occur following monocular deprivation earlyin the critical period. Inhibition of protein kinase G by Rp-8-Br-PET-cGMPS had no effect, indicating a specificity for the PKA pathway. Enhancement of PKA activity late in the critical period with Sp-8-C1-cAMPS did not increase plasticity. PKA is a necessary component of the pathway leading to cortical plasticity during the critical period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:46:50