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Titolo:
Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology
Autore:
Wu, GY; Deisseroth, K; Tsien, RW;
Indirizzi:
Stanford Univ, Sch Med, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 & Mol Physiol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 t & Behav Sci, Stanford, CA 94305 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 2, volume: 4, anno: 2001,
pagine: 151 - 158
SICI:
1097-6256(200102)4:2<151:SSSMPA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE CASCADE; LONG-TERM FACILITATION; ELEMENT-BINDING PROTEIN; SYNAPTIC ACTIVITY; CREB PHOSPHORYLATION; DEPENDENT REGULATION; RECEPTOR ACTIVATION; SIGNALING PATHWAY; HIPPOCAMPAL SLICE; SENSORY NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Tsien, RW Stanford Univ, Sch Med, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 iol, Stanford, CA 94305 USA
Citazione:
G.Y. Wu et al., "Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology", NAT NEUROSC, 4(2), 2001, pp. 151-158

Abstract

Memory storage in mammalian neurons probably depends on both biochemical events and morphological alterations in dendrites. Here we report an activity-dependent stabilization of the MAP kinase (MAPK) pathway, prominent in hippocampal dendrites. The longevity of the signal in these dendrites was increased to hours when multiple spaced stimuli were used. Likewise, spaced stimuli and MAPK activation were critical for protrusion of new dendritic filopodia that also remained stable for hours. Our experiments define a new role for stimulus-specific responses of MAPK signaling in activity-dependent neuronal plasticity. The local biochemical signaling in dendrites complements MAPK signaling in gene expression. Together, these processes may supportlong-lasting behavioral changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:40:09