Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories
Autore:
Jones, MW; Errington, ML; French, PJ; Fine, A; Bliss, TVP; Garel, S; Charnay, P; Bozon, B; Laroche, S; Davis, S;
Indirizzi:
Univ Paris Sud, CNRS, UMR 8620, Lab Neurobiol Apprentissage Memoire & Commun, F-91405 Orsay, France Univ Paris Sud Orsay France F-91405 oire & Commun, F-91405 Orsay, France Natl Inst Med Res, Div Neurophysiol, London NW7 1AA, England Natl Inst MedRes London England NW7 1AA hysiol, London NW7 1AA, England Ecole Normale Super, INSERM, U368, F-75230 Paris, France Ecole Normale Super Paris France F-75230 RM, U368, F-75230 Paris, France
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 3, volume: 4, anno: 2001,
pagine: 289 - 296
SICI:
1097-6256(200103)4:3<289:ARFTIE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; PROTEIN-SYNTHESIS; DENTATE GYRUS; HIPPOCAMPAL-NEURONS; SYNTHESIS INHIBITOR; RAT HIPPOCAMPUS; SPATIAL MEMORY; GROWTH-FACTOR; IN-VIVO; POTENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Davis, S Univ Paris Sud, CNRS, UMR 8620, Lab Neurobiol Apprentissage Memoire & Commun, F-91405 Orsay, France Univ Paris Sud Orsay France F-91405 mmun, F-91405 Orsay, France
Citazione:
M.W. Jones et al., "A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories", NAT NEUROSC, 4(3), 2001, pp. 289-296

Abstract

The induction of long-term potentiation (LTP) in the dentate gyrus of the hippocampus is associated with a rapid and robust transcription of the immediate early gene Zif268. We used a mutant mouse with a targeted disruption of Zif268 to ask whether this gene, which encodes a zinc finger transcription factor, is required for the maintenance of late LTP and for the expression of long-term memory. We show that whereas mutant mice exhibit early LTP in the dentate gyrus, late LTP is absent when measured 24 and 48 hours after tetanus in the freely moving animal. In both spatial and non-spatial learning tasks, short-term memory remained intact, whereas performance was impaired in tests requiring long-term memory. Thus, Zif268 is essential for thetransition from short- to long-term synaptic plasticity and for the expression of long-term memories.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:04:46