Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PLC-beta 1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex
Autore:
Hannan, AJ; Blakemore, C; Katsnelson, A; Vitalis, T; Huber, KM; Bear, M; Roder, J; Kim, D; Shin, HS; Kind, PC;
Indirizzi:
Univ Oxford, Physiol Lab, Oxford OX1 3PT, England Univ Oxford Oxford England OX1 3PT Physiol Lab, Oxford OX1 3PT, England Univ Edinburgh, Dept Biomed Sci, Edinburgh EH8 9XD, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9XD Midlothian, Scotland Brown Univ, Dept Neurosci, Providence, RI 02912 USA Brown Univ ProvidenceRI USA 02912 ept Neurosci, Providence, RI 02912 USA Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada Pohang Univ Sci & Technol, Dept Life Sci, Natl CRI Ctr Calcium & Learning,Pohang 790784, South Korea Pohang Univ Sci & Technol Pohang South Korea 790784 790784, South Korea
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 3, volume: 4, anno: 2001,
pagine: 282 - 288
SICI:
1097-6256(200103)4:3<282:P1AVMM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; LONG-TERM POTENTIATION; MOUSE SOMATOSENSORY CORTEX; CAT VISUAL-CORTEX; CRITICAL PERIOD; MONOAMINE-OXIDASE; BARREL CORTEX; POSTNATAL-DEVELOPMENT; PATTERN-FORMATION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Kind, PC Univ Oxford, Physiol Lab, Parks Rd, Oxford OX1 3PT, England Univ Oxford Parks Rd Oxford England OX1 3PT ord OX1 3PT, England
Citazione:
A.J. Hannan et al., "PLC-beta 1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex", NAT NEUROSC, 4(3), 2001, pp. 282-288

Abstract

During development of the cerebral cortex, the invasion of thalamic axons and subsequent differentiation of cortical neurons are tightly coordinated. Here we provide evidence that glutamate neurotransmission triggers a critical signaling mechanism involving the activation of phospholipase C-beta1 (PLC-beta1) by metabotropic glutamate receptors (mGluRs). Homozygous null mutation of either PLC-beta1 or mGluR5 dramatically disrupts the cytoarchitectural differentiation of 'barrels' in the mouse somatosensory cortex, despite segregation in the pattern of thalamic innervation. Furthermore, group 1mGluR-stimulated phosphoinositide hydrolysis is dramatically reduced in PLC-beta1(-/-) mice during barrel development. Our data indicate that PLC-beta1 activation via mGluR5 is critical for the coordinated development of theneocortex, and that presynaptic and postsynaptic components of cortical differentiation can be genetically dissociated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:03:24