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Titolo:
Amphetamine selectively blocks inhibitory glutamate transmission in dopamine neurons
Autore:
Paladini, CA; Fiorillo, CD; Morikawa, H; Williams, JT;
Indirizzi:
Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 m Inst, Portland, OR 97201 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 3, volume: 4, anno: 2001,
pagine: 275 - 281
SICI:
1097-6256(200103)4:3<275:ASBIGT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; EXCITATORY SYNAPTIC TRANSMISSION; RAT NUCLEUS-ACCUMBENS; SUBSTANTIA-NIGRA; RECEPTORS; COCAINE; LOCOMOTOR; MODULATION; PRAZOSIN; RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, JT Oregon Hlth Sci Univ, Vollum Inst, L474,3818 SW Sam Jackson Pk Rd, Portland, OR 97201 USA Oregon Hlth Sci Univ L474,3818 SW Sam Jackson Pk Rd Portland OR USA 97201
Citazione:
C.A. Paladini et al., "Amphetamine selectively blocks inhibitory glutamate transmission in dopamine neurons", NAT NEUROSC, 4(3), 2001, pp. 275-281

Abstract

Amphetamine is a highly addictive psychostimulant that promotes the release of the catecholamines dopamine and norepinephrine. Amphetamine-induced release of dopamine in the midbrain inhibits the activity of dopamine neuronsthrough activation of D-2 dopamine autoreceptors. Here we show that amphetamine may also excite dopamine neurons through modulation of glutamate neurotransmission. Amphetamine potently inhibits metabotropic glutamate receptor (mGluR)-mediated IPSPs in dopamine neurons, but has no effect on ionotropic glutamate receptor-mediated EPSCs. Amphetamine desensitizes the mGluR-mediated hyperpolarization through release of dopamine, activation of postsynaptic alpha (1) adrenergic receptors, and suppression of InsP(3)-induced calcium release from internal stores. By selectively suppressing the inhibitory component of glutamate-mediated transmission, amphetamine may promote burst firing of dopamine neurons. Through this mechanism, amphetamine may enhance phasic release of dopamine, which is important in the neural processing of reward.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:51:26