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Titolo:
Nuclear calcium signaling controls CREB-mediated gene expression triggeredby synaptic activity
Autore:
Hardingham, GE; Arnold, FJL; Bading, H;
Indirizzi:
MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC Cambridge England CB2 2QH , Mol Biol Lab, Cambridge CB2 2QH, England
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 3, volume: 4, anno: 2001,
pagine: 261 - 267
SICI:
1097-6256(200103)4:3<261:NCSCCG>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT PROTEIN-KINASE; HIPPOCAMPAL-NEURONS; DIFFERENTIAL ACTIVATION; CYTOPLASMIC CALCIUM; PYRAMIDAL NEURONS; ACTION-POTENTIALS; TERNARY COMPLEX; TRANSCRIPTION; PHOSPHORYLATION; GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Bading, H MRC, Mol Biol Lab, Hills Rd, Cambridge CB2 2QH, England MRC Hills Rd Cambridge England CB2 2QH mbridge CB2 2QH, England
Citazione:
G.E. Hardingham et al., "Nuclear calcium signaling controls CREB-mediated gene expression triggeredby synaptic activity", NAT NEUROSC, 4(3), 2001, pp. 261-267

Abstract

Information storage in the nervous system requires transcription triggeredby synaptically evoked calcium signals. It has been suggested that translocation of calmodulin into the nucleus, initiated by submembranous calcium transients, relays synaptic signals to CREB. Here we show that in hippocampal neurons, signaling to CREB can be activated by nuclear calcium alone and does not require import of cytoplasmic proteins into the nucleus. The nucleus is particularly suited to integrate neuronal firing patterns, and specifies the transcriptional outputs through a burst frequency-to-nuclear calcium amplitude conversion. Calcium release from intracellular stores promotes calcium wave propagation into the nucleus, which is critical for CREB-mediated transcription by synaptic NMDA receptors. Pharmacological or genetic modulation of nuclear calcium may directly affect transcription-dependent memory and cognitive functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:35:43