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Titolo:
DNA mismatch repair and cancer
Autore:
Peltomaki, P;
Indirizzi:
Ohio State Univ, Ctr Comprehens Canc, Div Human Canc Genet, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 Canc Genet, Columbus, OH 43210 USA
Titolo Testata:
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
fascicolo: 1, volume: 488, anno: 2001,
pagine: 77 - 85
SICI:
1383-5742(200103)488:1<77:DMRAC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPOLYPOSIS COLORECTAL-CANCER; TRANSCRIPTION-COUPLED REPAIR; MICROSATELLITE INSTABILITY; COLON-CANCER; SACCHAROMYCES-CEREVISIAE; GENOMIC INSTABILITY; ALKYLATING-AGENTS; REPLICATION ERROR; CELL-LINES; MUTATIONS;
Keywords:
carcinogenesis; colon cancer; DNA mismatch repair; HNPCC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Peltomaki, P Ohio State Univ, Ctr Comprehens Canc, Div Human Canc Genet, 690 Med Rea Facil,420 W 12th Ave, Columbus, OH 43210 USA Ohio State Univ 690Med Rea Facil,420 W 12th Ave Columbus OH USA 43210
Citazione:
P. Peltomaki, "DNA mismatch repair and cancer", MUT RES-R M, 488(1), 2001, pp. 77-85

Abstract

Five human DNA mismatch repair genes have been identified that, when mutated, cause susceptibility to hereditary nonpolyposis colorectal cancer (HNPCC). Mutational inactivation of both copies of a DNA mismatch repair gene results in a profound repair defect and progressive accumulation of mutationsthroughout the genome. Some of the mutations confer selective advantage onthe cells, giving rise to cancer. Recent discoveries suggest that apart from postreplication repair, DNA mismatch repair proteins have several other functions that are highly relevant to carcinogenesis. These include DNA damage surveillance, prevention of recombination between nonidentical sequences and participation in meiotic processes (chromosome pairing). A brief overview of these different features of the human DNA mismatch repair system will be provided, with the emphasis in their implications in cancer development. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 06/04/20 alle ore 08:36:42