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Titolo:
Genotoxicity of streptonigrin: a review
Autore:
Bolzan, AD; Bianchi, MS;
Indirizzi:
IMBICE, Lab Cytogenet & Mutagensis, RA-1900 La Plata, Argentina IMBICE LaPlata Argentina RA-1900 utagensis, RA-1900 La Plata, Argentina
Titolo Testata:
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
fascicolo: 1, volume: 488, anno: 2001,
pagine: 25 - 37
SICI:
1383-5742(200103)488:1<25:GOSAR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SISTER-CHROMATID EXCHANGE; ATAXIA-TELANGIECTASIA CELLS; ANTITUMOR ANTIBIOTIC STREPTONIGRIN; OXIDOREDUCTASE DT-DIAPHORASE; GIEMSA-STAINED CHROMOSOMES; IN-SITU HYBRIDIZATION; TESTER STRAIN TA102; HUMAN-LYMPHOCYTES; DNA-DAMAGE; REACTIVE OXYGEN;
Keywords:
streptonigrin; genotoxicity; bruneomycin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
126
Recensione:
Indirizzi per estratti:
Indirizzo: Bolzan, AD IMBICE, Lab Cytogenet & Mutagensis, CC 403, RA-1900 La Plata, Argentina IMBICE CC 403 La Plata Argentina RA-1900 0 La Plata, Argentina
Citazione:
A.D. Bolzan e M.S. Bianchi, "Genotoxicity of streptonigrin: a review", MUT RES-R M, 488(1), 2001, pp. 25-37

Abstract

Streptonigrin (SN, CAS no. 3930-19-6) is an aminoquinone antitumor antibiotic isolated from cultures of Streptomyces flocculus. This compound is a member of a group of antitumor agents which possess the aminoquinone moiety and that includes also mitomycin C, porfiromycin, actinomycin, rifamycin andgeldanamycin. Because of the potential use of SN in clinical chemotherapy,the study of its genotoxicity has considerable practical significance. SN inhibits the synthesis of DNA and RNA, causes DNA strand breaks after reduction with NADH, induces unscheduled DNA synthesis and DNA adducts and inhibits topoisomerase II. At the chromosome level, this antibiotic causes chromosome damage and increases the frequency of sister-chromatid exchanges. SN cleaves DNA in cell-free systems by a mechanism that involves complexing with metal ions and autoxidation of the quinone moiety to semiquinone in the presence of NADH with production of oxygen-derived reactive species. Recent evidence strongly suggests that the clastogenic action of this compound is partially mediated by free radicals. The present review aims at summarizing past and current knowledge concerning the genotoxic effects of SN. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 08:47:55