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Titolo:
Stimulation of DNA repair by the spermatidal TP1 protein
Autore:
Caron, N; Veilleux, S; Boissonneault, G;
Indirizzi:
Univ Sherbrooke, Fac Med, Dept Biochim, Sherbrooke, PQ J1H 5N4, Canada Univ Sherbrooke Sherbrooke PQ Canada J1H 5N4 erbrooke, PQ J1H 5N4, Canada
Titolo Testata:
MOLECULAR REPRODUCTION AND DEVELOPMENT
fascicolo: 4, volume: 58, anno: 2001,
pagine: 437 - 443
SICI:
1040-452X(200104)58:4<437:SODRBT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EJACULATED HUMAN SPERMATOZOA; TRANSITION PROTEIN-1; CHROMATIN STRUCTURE; STRAND BREAKS; TRANSLATIONAL REGULATION; ELONGATING SPERMATIDS; INCREASED SENSITIVITY; NUCLEOTIDE-SEQUENCE; ENDOGENOUS NICKS; TOPOISOMERASE-II;
Keywords:
spermatogenesis; UV irradiation; DNA single-strand breaks; DNA condensation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Boissonneault, G Univ Sherbrooke, Fac Med, Dept Biochim, 3001 12ieme Ave Nord, Sherbrooke, PQ J1H 5N4, Canada Univ Sherbrooke 3001 12ieme Ave Nord Sherbrooke PQ Canada J1H 5N4
Citazione:
N. Caron et al., "Stimulation of DNA repair by the spermatidal TP1 protein", MOL REPROD, 58(4), 2001, pp. 437-443

Abstract

The chromatin remodeling process that takes place during spermiogenesis inmammals is characterized by a transient increase in DNA single-strand breaks (SSB). The mammalian transition proteins (TPs) are expressed at a high level at mid-spermiogenesis steps coincident with chromatin remodeling and could be involved in the repair of these lesions since SSB are no longer detected in terminally differentiated spermatids. We report that TP1 can stimulate the repair of SSB in vitro and demonstrate that in vivo repair of UV-induced DNA lesions is enhanced in mammalian cells stably expressing TP1. These results suggest that, aside from its role in DNA compaction, this majortransition protein may contribute to the yet unidentified enzymatic activity responsible for the repair of SSB at mid-spermiogenesis steps. These results also suggest that the TP1 proteins have the potential to participate in the repair process following genotoxic insults and therefore may play an active role in the maintenance of the integrity of the male haploid genome during spermiogenesis. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 08:50:30