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Titolo:
Activation of heat shock transcription factor in yeast is not influenced by the levels of expression of heat shock proteins
Autore:
Hjorth-Sorensen, B; Hoffmann, ER; Lissin, NM; Sewell, AK; Jakobsen, BK;
Indirizzi:
Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Oxford OX3 9DS, England Univ Oxford Oxford England OX3 9DS Inst Mol Med, Oxford OX3 9DS, England
Titolo Testata:
MOLECULAR MICROBIOLOGY
fascicolo: 4, volume: 39, anno: 2001,
pagine: 914 - 923
SICI:
0950-382X(200102)39:4<914:AOHSTF>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING PROTEIN; SACCHAROMYCES-CEREVISIAE; NEGATIVE REGULATION; STRESS-RESPONSE; HSP70 GENE; IN-VIVO; HSP90 CHAPERONE; FACTOR HSF1; HELA-CELLS; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Jakobsen, BK Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Oxford OX3 9DS, England Univ Oxford Oxford England OX3 9DS Oxford OX3 9DS, England
Citazione:
B. Hjorth-Sorensen et al., "Activation of heat shock transcription factor in yeast is not influenced by the levels of expression of heat shock proteins", MOL MICROB, 39(4), 2001, pp. 914-923

Abstract

Heat shock transcription factor (HSF) transiently induces the expression of a universally conserved set of proteins, the heat shock proteins (Hsps), when cells are exposed to elevated temperatures as well as to a wide range of other environmental stresses. The tight control of heat shock gene expression has prompted a model, according to which HSF activity and 'free' heatshock protein levels are tied up in a regulatory loop. Other data have indicated that HSF senses stress directly. Here, we report that yeast cells inwhich the basal expression levels of Hsps have been significantly increased exhibit improved thermotolerance but display no detectable difference in the temperature required for transient activation of HSF. In a separate experiment, overexpression of SSA2, a member of the Hsp70 family and a prominent candidate for the feedback regulation of HSF, did not inhibit the heat shock response. Our findings challenge the dogma that relief of the suppression of HSF activity by Hsps can account for the acute heat shock response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:04:58