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Titolo:
Correcting partial volume artifacts of the arterial input function in quantitative cerebral perfusion MRI
Autore:
van Osch, MJP; Vonken, EJPA; Bakker, CJG; Viergever, MA;
Indirizzi:
Univ Utrecht Hosp, Dept Radiol, Image Sci Inst, Utrecht, Netherlands Univ Utrecht Hosp Utrecht Netherlands ge Sci Inst, Utrecht, Netherlands
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 3, volume: 45, anno: 2001,
pagine: 477 - 485
SICI:
0740-3194(200103)45:3<477:CPVAOT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; CONTRAST; ANGIOGRAPHY;
Keywords:
partial volume artifacts; arterial input function; dynamic susceptibility contrast MRI (DSC-MRI); cerebral perfusion; contrast agents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: van Osch, MJP UMC, Room E01-334,Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands UMC Room E01-334,Heidelberglaan 100 Utrecht Netherlands NL-3584 CX
Citazione:
M.J.P. van Osch et al., "Correcting partial volume artifacts of the arterial input function in quantitative cerebral perfusion MRI", MAGN RES M, 45(3), 2001, pp. 477-485

Abstract

To quantify cerebral perfusion with dynamic susceptibility contrast MRI (DSC-MRI), one needs to measure the arterial input function (AIF). Conventionally, one derives the contrast concentration from the DSC sequence by monitoring changes in either the amplitude or the phase signal on the assumptionthat the signal arises completely from blood. In practice, partial volume artifacts are inevitable because a compromise has to be reached between thetemporal and spatial resolution of the DSC acquisition. As the concentration of the contrast agent increases, the vector of the complex blood signal follows a spiral-like trajectory. In the case of a partial-volume voxel, the spiral is located around the static contribution of the surrounding tissue. If the static contribution of the background tissue is disregarded, estimations of the contrast concentration will be incorrect. By optimizing the correspondence between phase information and amplitude information one can estimate the origin of the spiral, and thereupon correct for partial volumeartifacts. This correction is shown to be accurate at low spatial resolutions for phantom data and to improve the AIF determination in a clinical example. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:03:38