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Titolo:
3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties
Autore:
Kobayashi, H; Sato, N; Hiraga, A; Saga, T; Nakamoto, Y; Ueda, H; Konishi, J; Togashi, K; Brechbiel, MW;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Diagnost & Intervent Imagiol, Hitachi Med Co Chair,Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 d Co Chair,Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Dept Nucl Med & Diagnost Imaging, Kyoto, Japan Kyoto Univ Kyoto Japan , Dept Nucl Med & Diagnost Imaging, Kyoto, Japan Kyoto Univ, Dept Radiol, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Dept Radiol, Kyoto, Japan NCI, Radioimmune & Inorgan Chem Sect, Radiat Oncol Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 adiat Oncol Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 3, volume: 45, anno: 2001,
pagine: 454 - 460
SICI:
0740-3194(200103)45:3<454:3AOMUM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GADOLINIUM CHLORIDE TOXICITY; GD-DTPA; MONOCLONAL-ANTIBODY; GLOMERULAR-FILTRATION; ENHANCING AGENT; BLOOD; ANGIOGENESIS; CANCER; RATS; BIODISTRIBUTION;
Keywords:
magnetic resonance imaging; angiography; microcirculation; contrast media; dendrimer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, H Kyoto Univ, Grad Sch Med, Dept Diagnost & Intervent Imagiol, Hitachi Med Co Chair,Sakyo Ku, 54 Kawahara Cho, Kyoto 6068507, Japan Kyoto Univ 54 Kawahara Cho Kyoto Japan 6068507 068507, Japan
Citazione:
H. Kobayashi et al., "3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties", MAGN RES M, 45(3), 2001, pp. 454-460

Abstract

Four novel macromolecular MRI contrast agents, all of which had the same chemical composition but different molecular weights, were prepared using generation-3, -4, -5, and -6 polyamidoamine (PAMAM(TM)) dendrimers conjugatedwith a bifunctional diethylenetriaminepentaacetic acid derivative to change the blood retention, tissue perfusion, and excretion. Size-dependent changes in the pharmacokinetics were observed in the biodistribution study. Gd-153-labeled generation-6 PAMAM(TM)- conjugates remained in the blood significantly longer than all of the other preparations (P < 0.001). The increasein blood-to-organ ratio of the preparations was found to correlate with increasing molecular size (P < 0.001). Additionally, 3D-micro MR images and angiography of mice of high quality and detail were obtained using PAMAM(TM)-(1B4M-Gd)x as a macro-molecular MRI contrast agent with a 1.5-T clinical MRI instrument. Numerous fine vessels of similar to 200 mum diameter were visualized on subtracted 3D-MR angiographms with G6D-(1B4M-Gd)(192). The quality of the images was sufficient to estimate the microvasculature of cancerous tissue for anti-angiogenesis therapy and to investigate knockout mice. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:20:39