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Titolo:
In vivo measurement of the size of lipid droplets in an intracerebral glioma in the rat
Autore:
Lahrech, H; Zoula, S; Farion, R; Remy, C; Decorps, M;
Indirizzi:
Univ Grenoble 1, Hop Albert Michallon, INSERM, Unite Mixte, Grenoble, France Univ Grenoble 1 Grenoble France , INSERM, Unite Mixte, Grenoble, France
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 3, volume: 45, anno: 2001,
pagine: 409 - 414
SICI:
0740-3194(200103)45:3<409:IVMOTS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; H-1 MR SPECTROSCOPY; METASTATIC BRAIN-TUMORS; STIMULATED ECHOES; SELF-DIFFUSION; MOBILE LIPIDS; SPIN-ECHO; IN-VIVO; EX-VIVO; INVIVO;
Keywords:
rat C6 glioma; lipid droplets; diffusion coefficient measurement; in vivo restricted diffusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Lahrech, H CHU Grenoble, INSERM U438, Pavillon B,BP 217, F-38043 Grenoble 9, France CHU Grenoble Pavillon B,BP 217 Grenoble France 9 ble 9, France
Citazione:
H. Lahrech et al., "In vivo measurement of the size of lipid droplets in an intracerebral glioma in the rat", MAGN RES M, 45(3), 2001, pp. 409-414

Abstract

Pulsed field gradient NMR was used to measure the root mean square displacement lambda of the NMR visible lipid molecules in C6 brain tumors in the rat at different diffusion times. For a distribution of spherical droplets of diameter with volume fraction xi(Phi (i)), the mean characteristic droplet diameter Phi (c) = root Sigma (i)xi(Phi (i))Phi (2)(i) was shown to be related to the root mean square displacement at long diffusion times by the simple relationship Phi (2)(c) = 10 lambda (2). In the range of diffusion times 100-530 msec, lambda was found to be independent of the diffusion time and equal to 1.35 +/- 0.22 mum and Phi (c) to 4.27 +/- 0.71 mum. The data reinforce the notion that the presence of lipid resonances in NMR spectra oftumors is due to lipid droplets. Light microscopy of histologic slices showed the presence of lipid droplets mainly in the necrotic region and in a layer of tumor cells surrounding the necrosis. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 11:54:53