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Titolo:
Establishment of latent Epstein-Barr virus infection and stable episomal maintenance in murine B-cell lines
Autore:
Haan, KM; Aiyar, A; Longnecker, R;
Indirizzi:
Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 iol Immunol, Chicago, IL 60611 USA
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 6, volume: 75, anno: 2001,
pagine: 3016 - 3020
SICI:
0022-538X(200103)75:6<3016:EOLEVI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II; EPITHELIAL-CELLS; EBV RECOMBINANTS; DNA-REPLICATION; MAMMALIAN-CELLS; TRANSGENIC MICE; GENE-EXPRESSION; LYMPHOMA CELLS; HLA-DQ; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Longnecker, R Northwestern Univ, Sch Med, Dept Microbiol Immunol, Ward 6-231,303 E Chicago Ave, Chicago, IL 60611 USA Northwestern Univ Ward 6-231,303 E Chicago Ave Chicago IL USA 60611
Citazione:
K.M. Haan et al., "Establishment of latent Epstein-Barr virus infection and stable episomal maintenance in murine B-cell lines", J VIROLOGY, 75(6), 2001, pp. 3016-3020

Abstract

Epstein-Barr virus (EBV) is a strict human pathogen for which no small animal models exist. Plasmids that contain the EBV plasmid origin of replication, oriP, and express EBV nuclear antigen 1 (EBNA1) are stably maintained extrachromosomally in human cells, whereas these plasmids replicate poorly in rodent cells. However, the ability of oriP and EBNA1 to maintain the entire EBV episome in proliferating rodent cells has not been determined. Expression of the two human B-cell receptors for EBV on the surfaces of murine Bcells allows efficient viral entry that leads to the establishment of latent EBV infection and long-term persistence of the viral genome. Latent geneexpression in these cells resembles the latency II profile in that EBNA1 and LMP1 can be detected whereas EBNA2 and the EBNA3s are not expressed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:24:00