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Titolo:
Protein-DNA binding and CpG methylation at nucleotide resolution of latency-associated promoters Qp, Cp, and LMP1p of Epstein-Barr virus
Autore:
Salamon, D; Takacs, M; Ujvari, D; Uhlig, J; Wolf, H; Minarovits, J; Niller, HH;
Indirizzi:
Natl Ctr Epidemiol, Microbiol Res Grp, H-1522 Budapest, Hungary Natl Ctr Epidemiol Budapest Hungary H-1522 Grp, H-1522 Budapest, Hungary Natl Ctr Epidemiol, Microbiol Res Grp, H-1529 Budapest, Hungary Natl Ctr Epidemiol Budapest Hungary H-1529 Grp, H-1529 Budapest, Hungary Natl Ctr Epidemiol, Div Virol, H-1097 Budapest, Hungary Natl Ctr Epidemiol Budapest Hungary H-1097 rol, H-1097 Budapest, Hungary Semmelweis Univ Med, Fac Med, Dept Pathol 2, H-1091 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1091 2, H-1091 Budapest, Hungary Univ Regensburg, Inst Med Mikrobiol & Hyg, D-93053 Regensburg, Germany Univ Regensburg Regensburg Germany D-93053 , D-93053 Regensburg, Germany
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 6, volume: 75, anno: 2001,
pagine: 2584 - 2596
SICI:
0022-538X(200103)75:6<2584:PBACMA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOBLASTOID CELL-LINES; PHENOTYPE-DEPENDENT CONTROL; EBNA-1 GENE-TRANSCRIPTION; RESPONSIVE CIS-ELEMENT; LIGATION-MEDIATED PCR; NUCLEAR ANTIGEN-2; MEMBRANE-PROTEIN; BURKITTS-LYMPHOMA; LYMPHOCYTES-B; HOST-CELL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
113
Recensione:
Indirizzi per estratti:
Indirizzo: Niller, HH Natl Ctr Epidemiol, Microbiol Res Grp, Piheno Ut 1, H-1522 Budapest, Hungary Natl Ctr Epidemiol Piheno Ut 1 Budapest Hungary H-1522 Hungary
Citazione:
D. Salamon et al., "Protein-DNA binding and CpG methylation at nucleotide resolution of latency-associated promoters Qp, Cp, and LMP1p of Epstein-Barr virus", J VIROLOGY, 75(6), 2001, pp. 2584-2596

Abstract

Epstein-Barr viral (EBV) latency-associated promoters Qp, Cp, and LMP1p are crucial fur the regulated expression of the EBNA and LMP transcripts in dependence of the latency type. By transient transfection and in vitro binding analyses, many promoter elements and transcription factors have previously been shown to be involved in the activities of these promoters. However,the latency promoters have only partially been examined at the nucleotide level in vivo. Therefore, we undertook a comprehensive analysis of in vivo protein binding and CPG methylation patterns at these promoters in five representative cell lines and correlated the results with the known in vitro binding data and activities of these promoters from previous transfection experiments. Promoter activity inversely correlated with the methylation state of promoters, although Qp was a remarkable exception. Novel protein binding data were obtained for all promoters. For Cp, binding correlated well with promoter activity; for LMP1p and Qp, binding patterns looked similar regardless of promoter activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 03:53:26