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Titolo:
Aldosterone synthase (CYP11B2)-344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension
Autore:
Delles, C; Erdmann, J; Jacobi, J; Hilgers, KF; Fleck, E; Regitz-Zagrosek, V; Schmieder, RE;
Indirizzi:
Univ Erlangen Nurnberg, Dept Med Nephrol, Nurnberg, Germany Univ Erlangen Nurnberg Nurnberg Germany Med Nephrol, Nurnberg, Germany Humboldt Univ, Charite, Dept Med Cardiol, Berlin, Germany Humboldt Univ Berlin Germany Charite, Dept Med Cardiol, Berlin, Germany Deutsch Herzzentrum, Berlin, Germany Deutsch Herzzentrum Berlin GermanyDeutsch Herzzentrum, Berlin, Germany
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 3, volume: 37, anno: 2001,
pagine: 878 - 884
SICI:
0735-1097(20010301)37:3<878:AS(CPI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-II; BLOOD-PRESSURE; STEROID 11-BETA-HYDROXYLASE; MINERALOCORTICOID RECEPTOR; BINDING-SITES; GENE; CYP11B2; HEART; MASS; HYPERTROPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Schmieder, RE Univ Erlangen Nurnberg, Med Klin 4 4, Klinikum Nurnberg Sud,Breslauer Str201, D-90471 Nurnberg, Germany Univ Erlangen Nurnberg Breslauer Str 201 Nurnberg Germany D-90471
Citazione:
C. Delles et al., "Aldosterone synthase (CYP11B2)-344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension", J AM COL C, 37(3), 2001, pp. 878-884

Abstract

OBJECTIVES This study examined the association between the -344 C/T polymorphism of the human aldosterone synthase promoter and left ventricular structure in arterial hypertension. BACKGROUND Because of conflicting results from different studies, the mechanism of such an association, if any, has not been determined. METHODS We examined the aldosterone synthase promoter genotype in 120 young (age: 26 +/- 3 years) male, white subjects with normal or mildly elevatedblood pressure. Left ventricular structural parameters and urinary sodium excretion over 24 h before and after additional oral sodium load (6 g/day over 1 week) were determined. RESULTS Hypertensive subjects with the CC genotype had a greater left ventricular end-diastolic diameter bur smaller relative wall thickness than those with the TT genotype (54 +/- 2 vs. 50 +/- 4 mm, and 0.37 +/- 0.07 vs. 0.44 +/- 0.06 mm, respectively; p < 0.05). Hypertensive subjects with the TT genotype (n = 15) had a greater increase in urinary sodium excretion after oral sodium load than those with the CC genotype (n = 11) (135 +/- 95 vs. 24 +/- 133 mmol/liter/day; p < 0.05). Serum aldosterone levels were found tobe decreased after oral sodium load in hypertensive subjects with the TT and CT genotypes only (-37 +/- 45 and -38 +/- 51 pg/ml respectively; all p <0.01) but nut in those with the CC genotype (-12 +/- 30 pg/ml, n.s.). Suchdifferences were not found in normotensive subjects. CONCLUSIONS Hypertensive subjects with the -344 CC genotype of the aldosterone synthase promoter are characterized by a pattern of early eccentric left ventricular hypertrophy. Differences in renal sodium handling across thegenotypes might contribute to this finding. CT Am Coil Cardiol 2001;37:878-84) (C) 2001 by the American College of Cardiology.

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Documento generato il 13/12/18 alle ore 23:46:03