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Titolo:
Estradiol supplementation suppresses hyperventilation-induced attacks in postmenopausal women with variant angina
Autore:
Kawano, H; Motoyama, T; Hirai, N; Kugiyama, K; Ogawa, H; Yasue, H;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Cardiovasc Med, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 iovasc Med, Kumamoto 8608556, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 3, volume: 37, anno: 2001,
pagine: 735 - 740
SICI:
0735-1097(20010301)37:3<735:ESSHAI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT VASODILATION; CORONARY SPASTIC ANGINA; NITRIC-OXIDE; HEART-DISEASE; REACTIVE HYPEREMIA; ARTERY SPASM; ESTROGEN; ACETYLCHOLINE; PATHOGENESIS; RELAXATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kawano, H Kumamoto Univ, Sch Med, Dept Cardiovasc Med, 1-1-1 Honjo, Kumamoto 8608556, Japan Kumamoto Univ 1-1-1 Honjo Kumamoto Japan 8608556 8608556, Japan
Citazione:
H. Kawano et al., "Estradiol supplementation suppresses hyperventilation-induced attacks in postmenopausal women with variant angina", J AM COL C, 37(3), 2001, pp. 735-740

Abstract

OBJECTIVES We sought to examine whether estradiol (E-2) supplementation suppresses anginal attacks in women with variant angina. BACKGROUND Estrogen is known to improve endothelial function. Coronary spasm plays an important role in the pathogenesis of not only variant angina but also ischemic heart disease in general, and endothelial dysfunction seems to be involved in the pathogenesis of coronary spasm. METHODS Fifteen postmenopausal women with variant angina (mean age 54.2 years) were given a hyperventilation (HV) test, a provocation test for coronary spasm, in the early morning of day 1 (baseline), day 3 (after 2-day transdermal E-2 supplementation, 4 mg) and day 5 (after 2-day placebo administration). We measured the flow-mediated (endothelium-dependent) dilation (FMD) of the brachial artery with the ultrasound technique before each HV test. RESULTS The anginal attacks with ST segment elevation were induced by HV in all patients on days 1 and 5. However, no attacks were induced on day 3. Supplementation with E-2 augmented FMD (3.5 +/- 0.6*, 8.9 +/- 0.7 and 4.0 +/- 0.5* on days 1, 3 and 5, respectively; (p < 0.01 vs. day 3). The serum E-2 levels on days 1, 3 and 5 were 22.7 +/- 2.8*, 96.2 +/- 9.2 and 30.7 +/- 7.1* pg/ml, respectively (*p < 0.01 vs. day 3). CONCLUSIONS The present results demonstrated for the first time, to our knowledge, that E-2 supplementation suppresses the HV-induced attacks in women with variant angina, in part because of the improvement of endothelial function. (J Am Coil Cardiol 2001;37:735-40) (C) 2001 by the American Collegeof Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 16:39:38