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Titolo:
Regional cerebral blood flow abnormalities in early-onset obsessive-compulsive disorder: An exploratory SPECT study
Autore:
Busatto, GF; Buchpiguel, CA; Zamignani, DR; Garrido, GEJ; Glabus, MF; Rosario-Campos, MC; Castro, CC; Maia, A; Rocha, ET; McGuire, PK; Miguel, EC;
Indirizzi:
USP, Fac Med, Dept Psiquiat, Sch Med, BR-05403010 Sao Paulo, Brazil USP Sao Paulo Brazil BR-05403010 BCch Med, BR-05403010 Sao Paulo, Brazil USP, Sch Med, Dept Radiol, BR-05403010 Sao Paulo, Brazil USP Sao Paulo Brazil BR-05403010 BCRadiol, BR-05403010 Sao Paulo, Brazil Heart Hosp, Sanatorio Sirio Assoc, Nucl Med Sect, Sao Paulo, Brazil Heart Hosp Sao Paulo Brazil rio Assoc, Nucl Med Sect, Sao Paulo, Brazil Univ Edinburgh, Dept Med Phys, Edinburgh EH8 9YL, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9YL Midlothian, Scotland Inst Psychiat, Dept Med Psychol, London, England Inst Psychiat London England sychiat, Dept Med Psychol, London, England
Titolo Testata:
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
fascicolo: 3, volume: 40, anno: 2001,
pagine: 347 - 354
SICI:
0890-8567(200103)40:3<347:RCBFAI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; STRUCTURAL ABNORMALITIES; SYMPTOM PROVOCATION; FUNCTIONAL MRI; PAROXETINE; MOTOR; PREDICTORS; THALAMUS; FAMILY;
Keywords:
single photon emission computed tomography (SPECT); obsessive-compulsive disorder; anxiety disorders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Busatto, GF USP, Fac Med, Dept Psiquiat, Sch Med, Rua Ovidio Pires Campos S-N, BR-05403010 Sao Paulo, Brazil USP Rua Ovidio Pires Campos S-N Sao Paulo Brazil BR-05403010 BC
Citazione:
G.F. Busatto et al., "Regional cerebral blood flow abnormalities in early-onset obsessive-compulsive disorder: An exploratory SPECT study", J AM A CHIL, 40(3), 2001, pp. 347-354

Abstract

Objective: Recent epidemiological and clinical data suggest that obsessive-compulsive disorder (OCD) may be subtyped according the age of onset of obsessive-compulsive symptoms. The regional cerebral blood flow (rCBF) singlephoton emission computed tomography (SPECT) technique was used to investigate whether the pathophysiology of OCD differs between early- and late-onset OCD subjects. Method: Resting rCBF was measured in 13 early-onset (<10 years) and 13 late-onset (>12 years) adult OCD subjects and in 22 healthy controls. Voxel-based rCBF comparisons were performed with statistical parametric mapping. Results: Early-onset OCD cases showed decreased rCBF in the right thalamus, left anterior cingulate cortex, and bilateral inferior prefrontal cortex relative to late-onset subjects (p <.0005, uncorrected for multiple comparisons). Relative to controls, early-onset cases had decreased left anterior cingulate and right orbitofrontal rCBF, and increased rCBF in the right cerebellum, whereas late-onset subjects showed reduced right orbitofrontal rCBF and increased rCBF in the left precuneus. In early-onset subjects only, severity of obsessive-compulsive symptoms correlated positively with left orbitofrontal rCBF. Conclusions: rCBF differences in frontal-subcortical circuits between early-onset and late-onset OCD subjects were found, both in location and direction of changes. These results provide preliminary evidence that brain mechanisms in OCD may differ depending on the age at which symptoms are first expressed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:34:05