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Titolo:
Effect of dopamine infusion on hemodynamics after hepatic denervation
Autore:
Wise, PE; Wiley, DH; Drougas, JG; Marsh, J; Feurer, ID; Chapman, WC; Blair, KT; Wright, JK; Eddy, VA; Pinson, CW;
Indirizzi:
Vanderbilt Univ, Med Ctr, Div Hepatobiliary Surg & Liver Transplantat, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 nsplantat, Nashville, TN 37232 USA Nashville Vet Affairs Med Ctr, Div Hepatobiliary Surg & Liver Transplantat, Nashville, TN 37232 USA Nashville Vet Affairs Med Ctr Nashville TN USA 37232 hville, TN 37232 USA
Titolo Testata:
JOURNAL OF SURGICAL RESEARCH
fascicolo: 1, volume: 96, anno: 2001,
pagine: 23 - 29
SICI:
0022-4804(200103)96:1<23:EODIOH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR BED; BLOOD-FLOW; LIVER; DOGS; SWINE; REPERFUSION; METABOLISM; DOBUTAMINE;
Keywords:
liver transplantation; pig; porcine; hepatic hemodynamics; liver perfusion; dopamine; catecholamine; hepatic blood flow; hepatic denervation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Pinson, CW Vanderbilt Univ, Med Ctr, Div Hepatobiliary Surg & Liver Transplantat, 801Oxford House, Nashville, TN 37232 USA Vanderbilt Univ 801 OxfordHouse Nashville TN USA 37232 232 USA
Citazione:
P.E. Wise et al., "Effect of dopamine infusion on hemodynamics after hepatic denervation", J SURG RES, 96(1), 2001, pp. 23-29

Abstract

Background. The effects of dopamine (DA) on systemic hemodynamics are better understood than its: effects on hepatic hemodynamics, especially after liver denervation occurring during liver transplantation. Therefore, a porcine model was used to study DA's effects on hemodynamics after hepatic denervation,Materials and methods. Fifteen pigs underwent laparotomy for catheter and how probe placement. The experimental group (n = 7) also underwent hepatic denervation. After 1 week, all pigs underwent DA infusion at increasing doses (3-30 mcg/kg/min) while measuring hepatic parameters [portal vein flow (PVF), hepatic artery flow (HAF), total hepatic blood how (THBF = HAF + PVF), portal and hepatic vein pressures] and systemic parameters [heart rate (IIR), mean arterial pressure (MAP)]. Results. There was a significant increase in HAF from baseline to the 30 mcg/kg/min DA infusion rate (within-subjects P < 0.01), but the differences between the two groups were not significant. PVF and THBF showed large effects (increases) with denervation, but the increase in flow with DA infusionwas not present after denervation. Perihepatic pressures were un; changed by denervation or DA. Heart rate differed significantly between the controland denervated animals at baseline, 3, 6, 12 (all P < 0.05), and 30 mcg/kg/ min DA (P = 0.10). Control vs denervation MAP at baseline was 100 +/- 4 vs 98 +/- 4 Torr and at 30 mcg/kg/ min it was 110 +/- 3 vs 101 +/- 5 mm Hg,Conclusions. Hepatic flows tended to be higher aff;er denervation, HAF showed similar increases with DA in both control and denervation groups. Increases in PVF and THBF with DA infusion were not present after denervation. HR was significantly decreased and MAP tended to be lower after denervation. The HR and MAP response to DA was similar in both groups. Therefore, both denervation and DA infusion have an effect on systemic and hepatic hemodynamics. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:59:16