Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Continuous assessment of multiple vital physiological functions in conscious freely moving rats using telemetry and a plethysmography system
Autore:
Schierok, H; Markert, M; Pairet, M; Guth, B;
Indirizzi:
Boehringer Ingelheim KG, Pharma, Dept Pulm Res, Gen Pharmacol Grp, D-88397Biberach, Germany Boehringer Ingelheim KG Biberach Germany D-88397 -88397Biberach, Germany
Titolo Testata:
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
fascicolo: 3, volume: 43, anno: 2000,
pagine: 211 - 217
SICI:
1056-8719(200005/06)43:3<211:CAOMVP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Keywords:
telemetry; plethysmography; conscious rats; safety pharmacology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Guth, B Boehringer Ingelheim KG, Pharma, Dept Pulm Res, Gen Pharmacol Grp,Birkendorfer Str 65, D-88397 Biberach, Germany Boehringer Ingelheim KG Birkendorfer Str 65 Biberach Germany D-88397
Citazione:
H. Schierok et al., "Continuous assessment of multiple vital physiological functions in conscious freely moving rats using telemetry and a plethysmography system", J PHARM TOX, 43(3), 2000, pp. 211-217

Abstract

The general pharmacologist in the pharmaceutical industry is challenged togenerate physiologically relevant data on possible safety liabilities or on secondary therapeutic uses as early as possible in drug development. Thisimplies the need for efficient use of usually only small supplies of test article. For this reason, we have developed a new animal model combining various elements to provide a broad spectrum of data focussing on the so-called vital physiological functions: cardiovascular, respiratory, and central nervous system. This system uses rats chronically implanted with transmitters for the measurement of arterial pressure, EGG, and body temperature. Modification of the transmitters also allows for the simultaneous assessment of locomotor activity. Studies are performed with these rats in plethysmographs placed directly over the antenna units thus allowing for the additionalassessment of respiratory function in the same studies. Using this system,we can generate simultaneously a wide range of relevant physiological parameters in conscious rats with a modest requirement for test article. Such an approach is highly useful for getting early safety readouts of potential drug development candidates as well as for detecting possible secondary therapeutic actions of a drug. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:29:45