Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Synthesis of of beta-amyloid precursor peptide and presenilin segments
Autore:
Balaspiri, L; Langel, U;
Indirizzi:
Stockholm Univ, Dept Neurochem & Neurotoxicol, S-10691 Stockholm, Sweden Stockholm Univ Stockholm Sweden S-10691 xicol, S-10691 Stockholm, Sweden Hungarian Acad Sci, Cent Res Inst Chem, Budapest, Hungary Hungarian Acad Sci Budapest Hungary nt Res Inst Chem, Budapest, Hungary
Titolo Testata:
JOURNAL OF PEPTIDE SCIENCE
fascicolo: 1, volume: 7, anno: 2001,
pagine: 58 - 60
SICI:
1075-2617(200101)7:1<58:SOOBPP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; PROTEIN;
Keywords:
Alzheimer's disease; beta-amyloid precursor protein; presenilins; segments; solid-phase peptide synthesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
5
Recensione:
Indirizzi per estratti:
Indirizzo: Balaspiri, L Stockholm Univ, Dept Neurochem & Neurotoxicol, S-10691 Stockholm, Sweden Stockholm Univ Stockholm Sweden S-10691 1 Stockholm, Sweden
Citazione:
L. Balaspiri e U. Langel, "Synthesis of of beta-amyloid precursor peptide and presenilin segments", J PEPT SCI, 7(1), 2001, pp. 58-60

Abstract

It seems likely that the beta -amyloid precursor protein (APP) and the presenilins (PS-1/2) play important roles in the development of Alzheimer's disease (AD). Attempts to mimic the biochemical actions of these proteins areoften made by the application of fragments of these proteins. However, thesynthesis elf these segments by conventional methods of peptide synthesis is problematic. We have synthesized several C-terminal fragments of APP andPS-1/2 by solid-phase synthesis through combination of automatic and manual methods of synthesis. This permits solution of the 'difficult sequences' in the solid-phase synthesis of these peptides. Some details of the syntheses of nine segments are presented in this paper. Copyright (C) 2001 European Peptide Society and John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:17:51