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Titolo:
Treatment of carcinoma of the parotid gland: The results of a multicenter study
Autore:
Tullio, A; Marchetti, C; Sesenna, E; Brusati, R; Cocchi, R; Eusebi, V;
Indirizzi:
Hosp Parma, Dept Maxillofacial Surg, I-43100 Parma, Italy Hosp Parma Parma Italy I-43100 Maxillofacial Surg, I-43100 Parma, Italy Bufalini Hosp, Dept Maxillofacial Surg, Cesena, Italy Bufalini Hosp Cesena Italy Hosp, Dept Maxillofacial Surg, Cesena, Italy San Paolo Hosp, Dept Maxillofacial Surg, Milan, Italy San Paolo Hosp Milan Italy Hosp, Dept Maxillofacial Surg, Milan, Italy Bellaria Hosp, Dept Maxillofacial Surg, Bologna, Italy Bellaria Hosp Bologna Italy sp, Dept Maxillofacial Surg, Bologna, Italy Univ Bologna, Dept Pathol, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 , Dept Pathol, I-40126 Bologna, Italy
Titolo Testata:
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
fascicolo: 3, volume: 59, anno: 2001,
pagine: 263 - 270
SICI:
0278-2391(200103)59:3<263:TOCOTP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOID CYSTIC CARCINOMA; MAJOR SALIVARY-GLANDS; POSTOPERATIVE RADIOTHERAPY; MALIGNANT-TUMORS; COMBINED SURGERY; CANCER; EXPERIENCE; PROGNOSIS; PARALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Tullio, A Hosp Parma, Dept Maxillofacial Surg, Via Gramsci 14, I-43100 Parma, Italy Hosp Parma Via Gramsci 14 Parma Italy I-43100 3100 Parma, Italy
Citazione:
A. Tullio et al., "Treatment of carcinoma of the parotid gland: The results of a multicenter study", J ORAL MAX, 59(3), 2001, pp. 263-270

Abstract

Purpose: This study analyzed the prognostic factors for carcinoma of the parotid gland and the role of surgery alone or with radiotherapy in treatingthese lesions. Methods: Forty-five patients with malignant parotid tumors were studied retrospectively. Patients were treated by combined surgery and radiation therapy between 1984 and 1995 at the Maxillo-Facial Departments of the General Hospitals of Bologna and Parma. Resection was conservative when possible, depending on the extent of the tumor. The median follow-up time was 54 months. Data regarding incidence, tumor stage and grade, local control, distant metastases (calculated with the Kaplan-Meier method), and survival were analyzed. Cox's multiple linear regression was used to identify patient and tumor characteristics with the greatest prognostic significance. Results: The actuarial 5- and 8-year disease-free survival rates were 81% and 62%, respectively. Multivariate analysis showed that tumor stage was a more prognostic variable than tumor grade. Residual microscopic disease at the excision margins was also an important prognostic variable. Laterocervical metastases affected 4 patients (9%), and distant metastases appeared in8 patients (18%). Conclusions: Postoperative irradiation is indicated for patients with stage III and IV disease, patients with positive excision margins, and for patients with lymph node metastases. (C) 2001 American Association of Oral and Maxillofacial Surgeons.

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Documento generato il 01/10/20 alle ore 15:26:52