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Titolo:
Neural circuits regulating pulsatile luteinizing hormone release in the female guinea-pig: Opioid, adrenergic and serotonergic interactions
Autore:
Gore, A; Terasawa, E;
Indirizzi:
Univ Wisconsin, Neurosci Training Program, Madison, WI USA Univ WisconsinMadison WI USA Neurosci Training Program, Madison, WI USA
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 239 - 248
SICI:
0953-8194(200103)13:3<239:NCRPLH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHESUS-MONKEY; MEDIAN-EMINENCE; MENSTRUAL-CYCLE; GNRH NEURONS; RAT; NALOXONE; RECEPTORS; SECRETION; PEPTIDES; MODULATION;
Keywords:
opioid; serotonin; norepinephrine; LH; guinea-pig;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Gore, A Mt Sinai Sch Med, Neuobiol Aging Labs, Box 1639, New York, NY 10029 USA Mt Sinai Sch Med Box 1639 New York NY USA 10029 York, NY 10029 USA
Citazione:
A. Gore e E. Terasawa, "Neural circuits regulating pulsatile luteinizing hormone release in the female guinea-pig: Opioid, adrenergic and serotonergic interactions", J NEUROENDO, 13(3), 2001, pp. 239-248

Abstract

We studied three neurotransmitters involved in the regulation of pulsatileluteinizing hormone (LH) release: opioid peptides, serotonin and norepinephrine, using the ovariectomized guinea-pig. This is an attractive animal model due to the regularity of its LH pulses, enabling any disruptions to be clearly ascertained. In all experiments, a specific agonist or antagonist was administered, either alone or serially to enable detection of interactions, and effects on mean LH concentrations, pulse amplitude and interpulse interval were determined by PULSAR analysis. In the ovariectomized guinea-pig, catecholamines are stimulatory (acting through the alpha (1) and alpha (2) but not beta receptors, unlike other species), opioids inhibitory and serotonin permissively stimulatory to pulsatile LH release. Stimulatory effects of the opiate antagonist were not blocked by pretreatment with an alpha (1)- or alpha (2)-adrenergic antagonist. Similarly, pretreatment with the opiate antagonist did not prevent the suppression of LH release by alpha (1)and alpha (2) antagonists. This suggests that, in the guinea-pig, effects of opiates and catecholamines on LH release are exerted by independent pathways to luteinizing hormone releasing hormone (LHRH) neurones. For the opiate-serotonin interactions, pretreatment with the serotonergic antagonist did not block the stimulatory effect of the opiate antagonist on LH release. However, pretreatment with the opiate agonist could not be overcome by the serotonergic agonist, This suggests that the effects of the serotonin system on LHRH release may be indirectly mediated by opioid neurones. Taken together. these studies demonstrate that the three neurotransmitter systems studied are critically involved in normal pulsatile LH release in the female guinea-pig, and demonstrate novel functional relationships between the opioid and the adrenergic and serotonergic systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:28:48