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Titolo:
Insulin-like growth factor-I receptors and estrogen receptors interact in the promotion of neuronal survival and neuroprotection
Autore:
Garcia-Segura, LM; Cardona-Gomez, GP; Chowen, LA; Azcoitia, I;
Indirizzi:
CSIC, Inst Cajal, E-28002 Madrid, Spain CSIC Madrid Spain E-28002CSIC, Inst Cajal, E-28002 Madrid, Spain Hosp Nino Jesus, Unidad Invest, E-28009 Madrid, Spain Hosp Nino Jesus Madrid Spain E-28009 nidad Invest, E-28009 Madrid, Spain Univ Complutense Madrid, Fac Biol, Dept Biol Celular, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 ular, E-28040 Madrid, Spain
Titolo Testata:
JOURNAL OF NEUROCYTOLOGY
fascicolo: 5-6, volume: 29, anno: 2000,
pagine: 425 - 437
SICI:
0300-4864(200005/06)29:5-6<425:IGFRAE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; ACTIVATED PROTEIN-KINASE; CENTRAL-NERVOUS-SYSTEM; TRANSIENT FOREBRAIN ISCHEMIA; MPTP-INDUCED NEUROTOXICITY; PRIMARY CORTICAL-NEURONS; BREAST-CANCER CELLS; ESTRADIOL PROTECTS; ALZHEIMERS-DISEASE; OXIDATIVE STRESS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia-Segura, LM CSIC, Inst Cajal, E-28002 Madrid, Spain CSIC Madrid Spain E-28002 Cajal, E-28002 Madrid, Spain
Citazione:
L.M. Garcia-Segura et al., "Insulin-like growth factor-I receptors and estrogen receptors interact in the promotion of neuronal survival and neuroprotection", J NEUROCYT, 29(5-6), 2000, pp. 425-437

Abstract

Several in vitro and in vivo studies have shown that estrogen has neuroprotective properties. The neuroprotective effects of estrogen are probably exerted through several mechanisms, it is established that estrogen can provide neuroprotection by actions that are independent of estrogen receptor activation. In addition, in several experimental models, activation of estrogen receptors appears to be indispensable for neuroprotection. This review focuses on neuroprotection mediated by estrogen receptors. The interaction ofestrogen with growth factor receptor signaling to induce neuroprotection is discussed. Evidence is presented that estrogen receptors and insulin-likegrowth factor-I receptors interact in the promotion of neuronal survival and neuroprotection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 23:47:46