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Titolo:
Impact of high-flux/high-efficiency dialysis on folate and homocysteine metabolism
Autore:
Lasseur, C; Parrot, F; Delmas, Y; Level, C; Ged, C; Redonnet-Vernhet, I; Montaudon, D; Combe, C; Chauveau, P;
Indirizzi:
St Andre Hosp, Serv Nephrol & Hemodialysis, F-33075 Bordeaux, France St Andre Hosp Bordeaux France F-33075 dialysis, F-33075 Bordeaux, France
Titolo Testata:
JOURNAL OF NEPHROLOGY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 32 - 35
SICI:
1121-8428(200101/02)14:1<32:IOHDOF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL PLASMA HOMOCYSTEINE; HEMODIALYSIS-PATIENTS; FOLIC-ACID; HYPERHOMOCYSTEINEMIA; ATHEROSCLEROSIS; PYRIDOXINE; DISEASE; RISK;
Keywords:
folic acid plasma and erythrocyte concentration; folate therapeutic use; hemodialysis; vitamins; homocysteine plasma concentration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Lasseur, C St Andre Hosp, Serv Nephrol & Hemodialysis, 1 Rue Jean Burguet,F-33075 Bordeaux, France St Andre Hosp 1 Rue Jean Burguet Bordeaux FranceF-33075 rance
Citazione:
C. Lasseur et al., "Impact of high-flux/high-efficiency dialysis on folate and homocysteine metabolism", J NEPHROL, 14(1), 2001, pp. 32-35

Abstract

High-flux/high-efficiency (HF/HE) dialysis may have detrimental effects onmicro-nutrients and water-soluble vitamins, such as vitamin B6, whose levels are lowered. Folate deficiency may increase cardiovascular risk through an increase in homocysteine (Hcy) serum levels. We therefore investigated the effects of dialysis with a high-flux (HF) membrane on folate and Hcy metabolism. Twelve patients without any folate supplementation, receiving dialysis with a low-flux membrane prior to the study (T0), were switched to dialysis using a HF triacetate membrane for four months (T1, T2, T3, T4) and received an oral daily folate supplementation during the two last months (T3, T4). Mean predialysis plasma folate levels fell dramatically after one month ofHF dialysis (T1) and remained significantly lower than the initial level (p<0.05) at T2, Hcy concentrations were high in all patients at T0 (mean 47.3 +/- 17.6 <mu>M, normal range 5 to 15 muM). They did not change during thefirst two months of the study but dropped steeply after the beginning of oral folate supplementation. Folate supplementation should be used in HF/HE dialysis to avoid folate depletion. The combination of folate supplementation and HF/HE may lower Hcy levels and reduce cardiovascular morbidity and mortality in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:24:45