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Titolo:
Plasma sulfate concentration and hyperhomocysteinemia in hemodialysis patients
Autore:
Brunetti, M; Terracina, L; Timio, M; Saronio, P; Capodicasa, E;
Indirizzi:
Univ Perugia, Dept Internal Med, Biochem Sect, I-06122 Perugia, Italy UnivPerugia Perugia Italy I-06122 Biochem Sect, I-06122 Perugia, Italy
Titolo Testata:
JOURNAL OF NEPHROLOGY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 27 - 31
SICI:
1121-8428(200101/02)14:1<27:PSCAHI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC-RENAL-FAILURE; TOTAL HOMOCYSTEINE CONCENTRATION; SULFINIC ACID DECARBOXYLASE; GLOMERULAR-FILTRATION RATE; SULFUR AMINO-ACIDS; INORGANIC SULFATE; CYSTEINE; GLUTATHIONE; CATABOLISM; DIALYSIS;
Keywords:
sulfate; homocysteine; cysteine; hemodialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Brunetti, M Univ Perugia, Dept Internal Med, Biochem Sect, Via Giochetto, I-06122 Perugia, Italy Univ Perugia Via Giochetto Perugia Italy I-06122 rugia, Italy
Citazione:
M. Brunetti et al., "Plasma sulfate concentration and hyperhomocysteinemia in hemodialysis patients", J NEPHROL, 14(1), 2001, pp. 27-31

Abstract

Background: Severe hyperhomocysteinemia is common in hemodialysis patients, who also present a dramatic increase in plasma concentrations of sulfate,one of the main products of methionine and cysteine catabolism. The aim ofthis study was to verify the relationship between high plasma sulfate levels and cysteine or homocysteine concentrations in hemodialysis patients. Methods: Plasma sulfate, cysteine and homocysteine concentrations and somerenal efficiency parameters were determined in 18 patients with end-stage renal failure, all undergoing 4h hemodialysis three times a week. The pattern of post-dialysis rises on plasma concentrations of sulfate, cysteine andhomocysteine was established. Results: Plasma sulfate, cysteine and homocysteine levels were significantly higher in patients than in normal controls. Plasma sulfate concentrations positively correlated with cysteinemia (p = 0.031; r = 0.482) which, in turn correlated with homocysteinemia (p = 0.042; r = 0.460). Sulfate levels also correlated with blood creatinine (p = 0.004; r = 0.630), nitrogen (p =0.000; r = 0.899), protein (p = 0.014; r = 0.555), and albumin (p = 0.003;r = 0.642), Post-dialysis rises in sulfate and cysteine were detected somehours before homocysteine. Conclusion: The results suggest that high sulfate levels, due mainly to impaired renal function, are involved in the alterated metabolism of homocysteine in hemodialysis patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 18:52:05