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Titolo:
Correlation of VEGF with contrast enhancement on dual-phase dynamic helical CT in liver tumors: Preliminary study
Autore:
Kwak, BK; Shim, HJ; Park, US; Lee, TJ; Paeng, SS; Lee, CJ; Lim, HK; Park, CK;
Indirizzi:
Chung Ang Univ, Coll Med, Dept Radiol, Seoul 140757, South Korea Chung AngUniv Seoul South Korea 140757 adiol, Seoul 140757, South Korea Chung Ang Univ, Coll Med, Dept Pathol, Seoul 140757, South Korea Chung AngUniv Seoul South Korea 140757 athol, Seoul 140757, South Korea Sung Kyun Kwan Univ, Sch Med, Natl Med Ctr, Dept Pathol, Seoul, South Korea Sung Kyun Kwan Univ Seoul South Korea , Dept Pathol, Seoul, South Korea Sung Kyun Kwan Univ, Sch Med, Natl Med Ctr, Dept Diagnost Radiol, Seoul, South Korea Sung Kyun Kwan Univ Seoul South Korea agnost Radiol, Seoul, South Korea Sung Kyun Kwan Univ, Sch Med, Samsung Med Ctr, Dept Radiol, Seoul, South Korea Sung Kyun Kwan Univ Seoul South Korea , Dept Radiol, Seoul, South Korea Sung Kyun Kwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul, South Korea Sung Kyun Kwan Univ Seoul South Korea , Dept Pathol, Seoul, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 1, volume: 16, anno: 2001,
pagine: 83 - 87
SICI:
1011-8934(200102)16:1<83:COVWCE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-PERMEABILITY FACTOR; ENDOTHELIAL GROWTH-FACTOR; HUMAN BRAIN-TUMORS; INDUCED ANGIOGENESIS; FACTOR EXPRESSION; BREAST-TUMORS; PURIFICATION; INHIBITION; ANTIBODY;
Keywords:
vascular endothelial growth factor (VEGF); computed tomography, contrast enhancement; liver; liver neoplasms; liver neoplasms, blood supply; computed tomography, helical;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kwak, BK Chung Ang Univ, Coll Med, Yongsan Hosp, Dept Radiol,Yongsan Gu, 65 Hangangro 3 Ga, Seoul 140757, South Korea Chung Ang Univ 65 Hangangro 3 Ga Seoul South Korea 140757 Korea
Citazione:
B.K. Kwak et al., "Correlation of VEGF with contrast enhancement on dual-phase dynamic helical CT in liver tumors: Preliminary study", J KOR MED S, 16(1), 2001, pp. 83-87

Abstract

The purpose of this preliminary study is to elucidate that vascular endothelial growth factor (VEGF) influences contrast enhancement of hepatic tumors on computed tomography (CT). Fourteen patients with hepatic tumors (11 hepatocellular carcinomas; 3 metastatic cancers) underwent a dual-phase dynamic helical CT or computed tomographic hepatic arteriography, The attenuation of each mass was determined as hyperattenuation, isoattenuation or hypoattenuation with respect to the adjacent nontumorous parenchyma. Gun-needle biopsy was done for each tumor, and paraffin sections were immunostained with anti- VEGF antibody by the avidin-biotin-peroxidase complex method. The pathologic grade was made by intensity (1+, 2+, 3+) and area (+/-, 1+, 2+). The tumor ranged 2.0-14.0 cm in size (mean, 5.8 cm). In arterial phase, theintensity was not correlated with the degree of enhancement (p=0.086). However, the correlation between the attenuation value of hepatic arterial phase and the area of positive tumor cells was statistically significant (p=0.002). VEGF may be the factor that enhances the hepatic mass with water-soluble iodinated contrast agent in CT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:39:25