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Titolo:
Influence of stent expansion states on platelet deposition in an extracorporeal porcine arteriovenous shunt model using a multichannel perfusion chamber
Autore:
Ahn, T; Shin, E; Merhi, Y; Thai, P; Bilodeau, L;
Indirizzi:
Gachon Univ Hosp, Dept Internal Med, Namdong Gu, Inchon 405220, South Korea Gachon Univ Hosp Inchon South Korea 405220 u, Inchon 405220, South Korea Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada Montreal Heart Inst Montreal PQ Canada H1T 1C8 ntreal, PQ H1T 1C8, Canada Univ Montreal, Montreal, PQ, Canada Univ Montreal Montreal PQ CanadaUniv Montreal, Montreal, PQ, Canada
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 1, volume: 16, anno: 2001,
pagine: 31 - 38
SICI:
1011-8934(200102)16:1<31:IOSESO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSLUMINAL CORONARY ANGIOPLASTY; THREATENED CLOSURE; INTRAVASCULAR ULTRASOUND; FLOW CONDITIONS; SHEAR RATE; THROMBOSIS; COMPLICATIONS; IMPLANTATION; PREDICTORS; NEUTROPHIL;
Keywords:
blood platelets; stents; porcine model; perfusion chamber;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Ahn, T Gachon Univ Hosp, Dept Internal Med, Namdong Gu, 1198 Kuwol Dong, Inchon 405220, South Korea Gachon Univ Hosp 1198 Kuwol Dong Inchon South Korea 405220 h Korea
Citazione:
T. Ahn et al., "Influence of stent expansion states on platelet deposition in an extracorporeal porcine arteriovenous shunt model using a multichannel perfusion chamber", J KOR MED S, 16(1), 2001, pp. 31-38

Abstract

Limited data are available about incomplete stent expansion (SE) on platelet deposition (PD). We examined PD following different SE using an extracorporeal porcine arteriovenous shunt model to which a perfusion chamber with four parallel silastic tubes were connected. Blood flow was set at a 20 and100 mL/min in 1.8 and 3.1 mm diameter tubes, respectively. P154 stents were deployed completely (Group A, n=15) or incompletely (Group B, n=15) in 1.8 mm (n=13) and 3.1 mm (n=17) tubes. Cr-51-labelled platelet autologous blood was injected 1 hr before the perfusion. After 15 min-perfusion, the testing tubes were assessed for radioactivity counts. In-stent cross sectional area was measured by intravascular ultrasound. There was a significant difference in PD between group A and B regardless of channel size (118+/-18.4 vs 261.4+/-52.1 plts x 10(6)/cm(2), p<0.05). With adjusted shear rate and similar stenosis, PD was similar in both tubes. In smaller 1.8 mm tubes, a stenosis as subtle as 10% was associated with a significant PD difference (226.1+/-20 vs 112.9+/-20.5 plts x 10(6)/cm(2), p<0.005). This model enabled arepetitive, simultaneous comparison of PD following different SE states. It seems that the quality of SE remains crucial in smaller channels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:14:18