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Titolo:
DROPERIDOL CAUSES A DOSE-DEPENDENT PROLONGATION OF THE QT INTERVAL
Autore:
LISCHKE V; BEHNE M; DOELKEN P; SCHLEDT U; PROBST S; VETTERMANN J;
Indirizzi:
UNIV FRANKFURT KLINIKUM,DEPT ANESTHESIOL & RESUSCITAT,THEODOR STERN KAI 7 D-60596 FRANKFURT GERMANY
Titolo Testata:
Anesthesia and analgesia
fascicolo: 5, volume: 79, anno: 1994,
pagine: 983 - 986
SICI:
0003-2999(1994)79:5<983:DCADPO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUDDEN-DEATH; ANESTHESIA; HEART; DOGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
V. Lischke et al., "DROPERIDOL CAUSES A DOSE-DEPENDENT PROLONGATION OF THE QT INTERVAL", Anesthesia and analgesia, 79(5), 1994, pp. 983-986

Abstract

To further investigate possible prolongation of the frequency-corrected QT interval (QTc interval) after administration of droperidol (DRO), we studied 40 surgical patients who were randomly assigned to one ofthree groups, receiving an intravenous (IV) injection of either 0.1 mg/kg (Group 1, n = 10), 0.175 mg/kg (Group 2, n = 10), or 0.25 mg/kg (Group 3, n = 20) of DRO at induction of anesthesia. The QTc interval, heart rate, and arterial pressure were registered before and 1, 2, 3, 4, 5, 7.5, and 10 min after the respective dose injection. Significantprolongations of the median QTc interval were found in patients from all groups, ranging from 37 ms (8.0%) in Group 1, to 44 ms (10.6%) in Group 2, to 59 ms (14.9%) in Group 3, when compared with control. The heart rate showed a significant increase in all groups. Mean arterial pressure (MAP) was slightly but significantly decreased in Groups 1 and 3. Prolongation of the QTc interval is a predictable and dose-dependent side effect after injection of high-dose DRO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:14:10